关键词: 流行性出血热, 黑线姬鼠, 褐家鼠

Abstract: This experiment is meant to solve the Approaches of transimission of the virus of EHF in population of principal host animals of EHF in China, in order to make a further study and explanation of the route of"the human beings being infected by mice", we have performed an experimental study in the Gnotoflex Isolalor in our lab. The Result of experiment indicates that Apodemus agrarius and Rattus norvegicus, can be infected by all viral strains from the different sources (Zun Yi Hou Kan's strains from Apodemus agrarius and R₂₆'s strains from Yong Chun's Rattus norvegicus) and the different infectious routes (aerosal, feeding, nasal drip, scarification). From titer produced by experimental mice's specific IgG antibody, we know that Apodemus agrarius and Rattus norvegicus are easier to be infected through aerosal, Apodemus agrarius and Rattus norvegicus are more clearly seen to be more sensitive to the viral strains from own races. From titer of IgG antibody of EHF produced by Rattus norvegicus, we know that the titer produced by Rattus norvegicus is lower than that by Apodemus agrarius, whether this has something to do with the infective dose, requires to be studied further. This experiment proves further that these two kinds of experimental mice can be infected mutually with strains of both Apodemus agrartus and Rattus norveglcus. From this result, it is inferred that infectious areas of Apodemus type will gradually change into infectious areas of mixed type is the inevitable tendency. According to this, contral the number of Rattus norvegicus in an infectious area, not only can prevent infectious areas from being spreaded and enlarged but also will have important epidemtological significances for Blocking transmision from Apodemus agrarius to Rattus norvegicus.