中国媒介生物学及控制杂志 ›› 2009, Vol. 20 ›› Issue (2): 133-134.

• 论著 • 上一篇    下一篇

不同保存时间的溴敌隆粉剂、母液对大鼠和小鼠实验室药效观察

李贵昌刘京立李镜辉葛军旗   

  1. 中国疾病预防控制中心传染病预防控制所媒介生物控制室(北京 102206)
  • 收稿日期:2008-11-21 出版日期:2009-04-20 发布日期:2009-04-20
  • 作者简介:李贵昌(1969-),男,硕士,助理研究员,主要从事鼠类及鼠传疾病防制与研究工作。

Effect of bromadiolone stored for different periods on the rats and mice in laboratory

 LI Gui-ChangLiu-Jing-LiLi-Jing-HuiGe-Jun-Qi   

  1. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
  • Received:2008-11-21 Online:2009-04-20 Published:2009-04-20

摘要:

  【摘要】 目的 观察不同保存时间的溴敌隆母液、粉剂对药效的影响。方法 生产日期分别是1995年、1999年的溴敌隆粉剂和1995年、2000年的溴敌隆母液,分别配制成0.005%的毒饵,以大鼠和小鼠为实验对象,每组6只,做实验室无选择溴敌隆毒饵实验。结果 各组动物在喂食毒饵后,实验大鼠、小鼠全部死亡,大鼠最长存活7 d,小鼠最长存活13 d,经生存分析, 大鼠、小鼠存活时间对各种毒饵的差异均无统计学意义(大鼠:χ2=0.43,P=0.934;小鼠:χ2=7.07,P=0.070);保存时间分别为5~10年的溴敌隆母液和粉剂对大鼠、小鼠药效无变化。结论 溴敌隆粉剂和母液在适宜的保存条件下,药效至少在10年内未发生显著变化。

关键词: 溴敌隆, 保存时间, 无选择实验, 药效

Abstract:

  【Abstract】 Objective To study the effect of holding periods of bromadiolone powder and pure liquid on its control efficacy. Methods The production dates of bromadiolone powder were 1995 and 1999, and that of bromadiolone pure liquid were 1995 and 2000, respectively. Each of them was diluted into 0.005% bromadiolone baits. Six rats and mice were selected randomly to do no-choice experiment in the lab. Results The mortality of the tested rats and mice was 100%. The longest survival times of rats and mice were 7 days and 13 days, respectively. There was no significant difference between them(rats:χ2=0.43, P=0.934;mice: χ2=7.07, P=0.070). Bromadiolone powder and pure liquid was still effective after storage for 5-10 years. Conclusion The control efficacy of bromadiolone powder and liquid did not change within 10 years at the optimum storage condition.

Key words: Bromadiolone, Holding period, No choice experiment, Control efficacy

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