肾综合征出血热患者血清指标与病情程度关系研究

doi:10.11853/j.issn.1003.8280.2024.05.007

摘要/Abstract

摘要： 目的探讨血清降钙素原（PCT）及白蛋白（ALB）对肾综合征出血热（HFRS）患者病情程度预测的价值。方法采取回顾性调查方法,回顾性分析21例成人HFRS患者入院时的临床及实验室资料[包括白细胞（WBC）、血小板（PLT）、PCT、ALB、活化部分凝血活酶时间（APTT）]。t检验或Mann-Whitney U检验用于比较WBC、PLT、PCT、ALB、APTT水平在不同病情程度的差异；Spearman秩相关（偏态分布资料）、Pearson相关（正态分布资料）、二元logistic回归分析用于分析PCT、ALB对HFRS病情程度预测的统计学效力。结果重症组WBC、PCT、ALB水平均高于轻症组,差异有统计学意义（均P<0.05）,PLT和APTT水平在两组间的差异均无统计学意义（均P>0.05）。WBC、PCT与疾病严重程度呈正相关（r=0.471,P=0.031；r_s=0.819,P<0.001）,ALB与疾病严重程度呈负相关（r_s=-0.801,P<0.001）。PLT、APTT与疾病严重程度相关性无统计学意义（均P>0.05）。重症组的PCT、ALB水平与疾病严重程度独立相关[OR=7.812,95%置信区间（CI）：1.579～38.655,P=0.012；OR=0.713,95% CI：0.546～0.932,P=0.013]。结论血清PCT、ALB水平在一定程度上可以反映肾综合征出血热疾病严重程度,是HFRS严重程度的独立危险因素,具有较高的临床预测价值,其可作为评估HFRS严重程度早期预警指标。

关键词: 肾综合征出血热, 降钙素原, 白蛋白

Abstract: Objective To investigate the value of serum procalcitonin (PCT) and albumin (ALB) in predicting the severity of hemorrhagic fever with renal syndrome (HFRS). Methods A retrospective analysis was performed on the clinical and laboratory data of 21 adult patients with HFRS, involving white blood cells (WBC), platelets (PLT), PCT, ALB, and activated partial thromboplastin time (APTT). The t-test or Mann-Whitney U test was used to compare the differences in the levels of WBC, PLT, PCT, ALB and APTT in different disease severity groups. Spearman rank correlation (for skewed distribution data), Pearson correlation (for normal distribution data), binary logistic regression were used to analyze the statistical power of PCT and ALB in predicting the severity of HFRS. Results Compared with those in the mild group, the levels of WBC, PCT, and ALB in the severe group were significantly higher (all P<0.05), with no significant differences in the levels of PLT and APTT between the two groups (both P>0.05). The disease severity was positively correlated with WBC (r=0.471, P=0.031) and PCT (r_s=0.819, P<0.001) and negatively correlated with ALB (r_s=-0.801, P<0.001). There were no significant correlations between PLT and the severity of the disease, and between APTT and the severity (both P>0.05). In the severe group, PCT and ALB levels were independently correlated with the disease severity [OR=7.812,95% confidence interval (CI ): 1.579-38.655, P=0.012; OR=0.713,95% CI : 0.546-0.932, P=0.013]. Conclusion Serum PCT and ALB levels are independent risk factors reflecting the severity of HFRS, showing high clinical value as early warning parameters to assess the severity of HFRS.

Key words: Hemorrhagic fever with renal syndrome, Procalcitonin, Albumin

中图分类号:

R512.8
R183

邓乐, 钟恢海. 肾综合征出血热患者血清指标与病情程度关系研究[J]. 中国媒介生物学及控制杂志, 2024, 35(5): 547-551.

DENG Le, ZHONG Hui-hai. Relationship between serum parameters and the severity of hemorrhagic fever with renal syndrome[J]. Chinese Journal of Vector Biology and Control, 2024, 35(5): 547-551.

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