媒介蚊虫促进病毒感染调控的机制研究进展

doi:10.11853/j.issn.1003.8280.2023.04.026

摘要/Abstract

摘要：

蚊媒病毒在全球广泛存在并造成宿主感染风险，引起了人类蚊媒传染病如登革热、寨卡病毒病等发病持续上升和播散，严重威胁全球公共卫生安全。此类病毒为适应人和媒介蚊虫2种不同的宿主环境，已经进化出众多复杂的互作机制，以实现其生存、繁衍与传播。该文对近年来媒介蚊虫促进病毒感染调控的机制研究进行了综述。

关键词: 蚊虫, 蚊媒病毒, 促感染调控机制

Abstract:

Mosquito-borne viruses are a serious, global, and widespread threat to public health with the risk of infecting hosts, which cause the increasing incidence and spreading of mosquito-borne infectious diseases in human society, such as dengue fever and Zika virus disease. To adapt to the different host environments of humans and mosquitoes, the viruses have evolved various complex interaction mechanisms to achieve their survival, reproduction, and transmission. This paper reviews recent research on the regulatory mechanisms of mosquitoes promoting viral infection.

Key words: Mosquito, Mosquito-borne virus, Infection-promoting regulatory mechanism

中图分类号:

R384.1

娄紫微, 刘宏美, 程鹏. 媒介蚊虫促进病毒感染调控的机制研究进展[J]. 中国媒介生物学及控制杂志, 2023, 34(4): 585-588.

Zi-wei LOU, Hong-mei LIU, Peng CHENG. Research progress on regulatory mechanism of mosquito vectors promoting virus infection[J]. Chinese Journal of Vector Biology and Control, 2023, 34(4): 585-588.

参考文献 45

1	Huang YJS, Higgs S, Vanlandingham DL. Emergence and re-emergence of mosquito-borne arboviruses[J]. Curr Opin Virol, 2019, 34, 104-109. DOI
2	Weaver SC, Barrett AD. Transmission cycles, host range, evolution and emergence of arboviral disease[J]. Nat Rev Microbiol, 2004, 2 (10):789-801. DOI
3	Cheng G, Liu Y, Wang PH, et al. Mosquito defense strategies against viral infection[J]. Trends Parasitol, 2016, 32 (3):177-186. DOI
4	Bhatt S, Gething PW, Brady OJ, et al. The global distribution and burden of dengue[J]. Nature, 2013, 496 (7446):504-507. DOI
5	Romo H, Papa A, Kading R, et al. Comparative vector competence of north American Culex pipiens and Cx. quinquefasciatus for African and European lineage 2 West Nile viruses[J]. Am J Trop Med Hyg, 2018, 98 (6):1863-1869. DOI
6	Huang ZJ, Kingsolver MB, Avadhanula V, et al. An antiviral role for antimicrobial peptides during the arthropod response to Alphavirus replication[J]. J Virol, 2013, 87 (8):4272-4280. DOI
7	Turtle L, Solomon T. Japanese encephalitis: The prospects for new treatments[J]. Nat Rev Neurol, 2018, 14 (5):298-313. DOI
8	Lee WS, Webster JA, Madzokere ET, et al. Mosquito antiviral defense mechanisms: A delicate balance between innate immunity and persistent viral infection[J]. Parasit Vectors, 2019, 12 (1):165. DOI
9	Zhao LM, Alto BW, Smartt CT, et al. Transcription profiling for defensins of Aedes aegypti (Diptera: Culicidae) during development and in response to infection with Chikungunya and Zika viruses[J]. J Med Entomol, 2018, 55 (1):78-89. DOI
10	Liu K, Xiao CG, Xi SM, et al. Mosquito defensins enhance Japanese encephalitis virus infection by facilitating virus adsorption and entry within the mosquito[J]. J Virol, 2020, 94 (21):e01164-20. DOI
11	Liu K, Hou FX, Wahaab A, et al. Mosquito defensin facilitates Japanese encephalitis virus infection by downregulating the C6/36 cell-surface antiviral protein HSC70B[J]. Vet Microbiol, 2021, 253, 108971. DOI
12	Zininga T, Ramatsui L, Shonhai A. Heat shock proteins as immunomodulants[J]. Molecules, 2018, 23 (11):2846. DOI
13	Pujhari S, Brustolin M, Macias VM, et al. Heat shock protein 70 (HSP70) mediates Zika virus entry, replication, and egress from host cells[J]. Emerg Microbes Infect, 2019, 8 (1):8-16. DOI
14	Ren JP, Ding TB, Zhang W, et al. Does Japanese encephalitis virus share the same cellular receptor with other mosquito-borne flaviviruses on the C6/36 mosquito cells?[J]. Virol J, 2007, 4, 83. DOI
15	Chuang CK, Yang TH, Chen TH, et al. Heat shock cognate protein 70 isoform D is required for clathrin-dependent endocytosis of Japanese encephalitis virus in C6/36 cells[J]. J Gen Virol, 2015, 96 (Pt 4):793-803. DOI
16	Ghosh A, Desai A, Ravi V, et al. Chikungunya virus interacts with heat shock cognate 70 protein to facilitate its entry into mosquito cell line[J]. Intervirology, 2018, 60 (6):247-262. DOI
17	Paingankar MS, Gokhale MD, Deobagkar DN. Dengue-2-virus-interacting polypeptides involved in mosquito cell infection[J]. Arch Virol, 2010, 155 (9):1453-1461. DOI
18	Lubkowska A, Pluta W, Strońska A, et al. Role of heat shock proteins (HSP70 and HSP90) in viral infection[J]. Int J Mol Sci, 2021, 22 (17):9366. DOI
19	毕英杰, 谢晶莹. 热休克蛋白90在抗病毒免疫中作用的研究进展[J]. 中国生物制品学杂志, 2019, 32 (12):1428-1432. DOI
	Bi YJ, Xie JY. Progress in research on role of heat shock protein 90 in antiviral immunity[J]. Chin J Biologicals, 2019, 32 (12):1428-1432. DOI
20	Shang Q, Wu P, Huang HL, et al. Inhibition of heat shock protein 90 suppresses Bombyx mori nucleopolyhedrovirus replication in B. mori[J]. Insect Mol Biol, 2020, 29 (2):205-213. DOI
21	程功, 吴葩, Peng S, 等. 蚊肠道共生菌增强伊蚊对蚊媒病毒易感性[J]. 科学新闻, 2020, (2):74.
	Cheng G, Wu P, Peng S, et al. A gut commensal bacterium promotes mosquito permissiveness to arboviruses[J]. Sci News, 2020, (2):74.
22	Dennison NJ, Jupatanakul N, Dimopoulos G. The mosquito microbiota influences vector competence for human pathogens[J]. Curr Opin Insect Sci, 2014, 3, 6-13. DOI
23	Angleró-Rodríguez YI, Talyuli OAC, Blumberg BJ, et al. An Aedes aegypti-associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity[J]. eLife, 2017, 6, e28844. DOI
24	Wu P, Sun P, Nie KX, et al. A gut commensal bacterium promotes mosquito permissiveness to arboviruses[J]. Cell Host Microbe, 2019, 25 (1):101-112.e5. DOI
25	Caragata EP, Tikhe CV, Dimopoulos G. Curious entanglements: Interactions between mosquitoes, their microbiota, and arboviruses[J]. Curr Opin Virol, 2019, 37, 26-36. DOI
26	Liu K, Qian YJ, Jung YS, et al. mosGCTL-7, a C-type lectin protein, mediates Japanese encephalitis virus infection in mosquitoes[J]. J Virol, 2017, 91 (10):e01348-16. DOI
27	Liu Y, Zhang FC, Liu JY, et al. Transmission-blocking antibodies against mosquito C-type lectins for dengue prevention[J]. PLoS Pathog, 2014, 10 (2):e1003931. DOI
28	吴宇杰, 刘珊, 张溪, 等. 伊蚊C型凝集素mosGCTL-2是登革病毒感染相关的重要蛋白质(英文)[J]. 生物化学与生物物理进展, 2019, 46 (12):1187-1195. DOI
	Wu YJ, Liu S, Zhang X, et al. C-type lectin protein mosGCTL-2 from Aedes aegypti is a novel factor for dengue virus infection[J]. Prog Biochem Biophys, 2019, 46 (12):1187-1195. DOI
29	Krishnan MN, Ng A, Sukumaran B, et al. RNA interference screen for human genes associated with West Nile virus infection[J]. Nature, 2008, 455 (7210):242-245. DOI
30	刘博宇, 李盼, 杨桂连. C型凝集素受体在寄生虫感染免疫调节中的作用[J]. 中国寄生虫学与寄生虫病杂志, 2015, 33 (3):228-232.
	Liu BY, Li P, Yang GL. The immunomodulatory role of C-type lectin receptors in parasitic infection[J]. Chin J Parasitol Parasit Dis, 2015, 33 (3):228-232.
31	Su JX, Wang G, Li CX, et al. Screening for differentially expressed miRNAs in Aedes albopictus (Diptera: Culicidae) exposed to DENV-2 and their effect on replication of DENV-2 in C6/36 cells[J]. Parasit Vectors, 2019, 12 (1):44. DOI
32	Trobaugh DW, Klimstra WB. MicroRNA regulation of RNA virus replication and pathogenesis[J]. Trends Mol Med, 2017, 23 (1):80-93. DOI
33	Cai WJ, Pan YH, Cheng AC, et al. Regulatory role of host microRNAs in flaviviruses infection[J]. Front Microbiol, 2022, 13, 869441. DOI
34	Zhou YH, Liu YX, Yan H, et al. miR-281, an abundant midgut-specific miRNA of the vector mosquito Aedes albopictus enhances dengue virus replication[J]. Parasit Vectors, 2014, 7, 488. DOI
35	Su JX, Li CX, Zhang YM, et al. Identification of microRNAs expressed in the midgut of Aedes albopictus during dengue infection[J]. Parasit Vectors, 2017, 10 (1):63. DOI
36	Avila-Bonilla RG, Yocupicio-Monroy M, Marchat LA, et al. miR-927 has pro-viral effects during acute and persistent infection with dengue virus type 2 in C6/36 mosquito cells[J]. J Gen Virol, 2020, 101 (8):825-839. DOI
37	Avila-Bonilla RG, Yocupicio-Monroy M, Marchat LA, et al. Analysis of the miRNA profile in C6/36 cells persistently infected with dengue virus type 2[J]. Virus Res, 2017, 232, 139-151. DOI
38	Dubey SK, Shrinet J, Sunil S. Aedes aegypti microRNA, miR-2944b-5p interacts with 3'UTR of Chikungunya virus and cellular target vps-13 to regulate viral replication[J]. PLoS Negl Trop Dis, 2019, 13 (6):e0007429. DOI
39	Maharaj PD, Widen SG, Huang J, et al. Discovery of mosquito saliva microRNAs during CHIKV infection[J]. PLoS Negl Trop Dis, 2015, 9 (1):e0003386. DOI
40	Xu TL, Sun YW, Feng XY, et al. Development of miRNA-based approaches to explore the interruption of mosquito-borne disease transmission[J]. Front Cell Infect Microbiol, 2021, 11, 665444. DOI
41	Sun P, Nie KX, Zhu YB, et al. A mosquito salivary protein promotes flavivirus transmission by activation of autophagy[J]. Nat Commun, 2020, 11 (1):260. DOI
42	王朝阳, 陈小芳, 程功. 媒介蚊虫唾液蛋白调控蚊媒病毒传播的研究进展[J]. 中国媒介生物学及控制杂志, 2021, 32 (6):653-659. DOI
	Wang CY, Chen XF, Cheng G. Research progress on the regulation of mosquito-borne virus transmission by mosquito salivary proteins[J]. Chin J Vector Biol Control, 2021, 32 (6):653-659. DOI
43	Valenzuela-Leon PC, Shrivastava G, Martin-Martin I, et al. Multiple salivary proteins from Aedes aegypti mosquito bind to the Zika virus envelope protein[J]. Viruses, 2022, 14 (2):221. DOI
44	Wichit S, Diop F, Hamel R, et al. Aedes aegypti saliva enhances Chikungunya virus replication in human skin fibroblasts via inhibition of the type Ⅰ interferon signaling pathway[J]. Infect Genet Evol, 2017, 55, 68-70. DOI
45	Sri-In C, Weng SC, Chen WY, et al. A salivary protein of Aedes aegypti promotes dengue-2 virus replication and transmission[J]. Insect Biochem Mol Biol, 2019, 111, 103181. DOI

[1]	马丽华, 韩晓莉, 高文, 王喜明, 赵勇, 宋纪文. 河北省2011－2022年成蚊生态学监测结果分析[J]. 中国媒介生物学及控制杂志, 2023, 34(4): 508-512,547.
[2]	刘全超, 朱丁, 邹亚明, 兰策介, 金辉. 江苏省无锡市2012－2021年蚊虫生态学监测结果分析[J]. 中国媒介生物学及控制杂志, 2023, 34(4): 513-517.
[3]	地里努尔·帕尔汗德, 郑小英, 吴忠道, 潘文杰, 张东京. 蚊虫肠道微生物在辐照不育技术中的应用前景[J]. 中国媒介生物学及控制杂志, 2023, 34(4): 579-584.
[4]	金彬彬, 韦凌娅, 曹阳, 邵汉文, 王英红, 孔庆鑫. 杭州市2017－2021年蚊虫种群密度与季节消长监测结果分析[J]. 中国媒介生物学及控制杂志, 2023, 34(3): 351-355.
[5]	王蓉, 刘起勇, 陆涛, 张宪青, 马永成, 郭玉红, 马斌忠, 刘桂香, 蒋明霞, 程晓兰. 青海省黄河流域人居环境蚊类物种组成及空间分布特征[J]. 中国媒介生物学及控制杂志, 2023, 34(3): 389-393.
[6]	田鹏, 孙晓东, 段凯霞, 徐艳春, 周耀武, 郭祥瑞, 李仕刚, 林祖锐. 缅甸拉咱市2018年蚊类和按蚊疟原虫子孢子感染调查[J]. 中国媒介生物学及控制杂志, 2023, 34(3): 412-416.
[7]	姜宁, 马雅军, 白洁, 彭恒. 蚊媒携带病毒现场检测方法研发趋势探讨[J]. 中国媒介生物学及控制杂志, 2023, 34(3): 422-427.
[8]	邓惠, 刘礼平, 高可, 段金花, 陈宗晶, 芦瑞鹏, 沈秀婷, 阴伟雄, 秦冰, 吴军, 林立丰. BG-home诱蚊器对常见蚊虫诱捕效果的实验测定及评价研究[J]. 中国媒介生物学及控制杂志, 2022, 33(6): 776-780.
[9]	郭旭东, 赵荣涛, 袁正泉, 徐路, 王申, 刘羽, 杨振洲, 石华. 基于无人机的捕虫装备设计与应用初探[J]. 中国媒介生物学及控制杂志, 2022, 33(6): 865-868.
[10]	李炳辉, 刘砚涛, 马小芳, 王伟, 宋富成, 孙庚晓, 姜洪荣, 付齐齐. 媒介蚊虫季节消长趋势分析方法的探讨与比较[J]. 中国媒介生物学及控制杂志, 2022, 33(6): 869-872.
[11]	陈红, 单宁, 周毅彬. 上海市静安区冬季地下车库蚊虫孳生影响因素研究[J]. 中国媒介生物学及控制杂志, 2022, 33(5): 710-714.
[12]	臧传慧, 公茂庆, 刘宏美. 蚊虫肠道微生物多样性及其功能的研究进展[J]. 中国媒介生物学及控制杂志, 2022, 33(4): 608-612.
[13]	王巧燕, 王韶华, 武峥嵘, 钟培松, 冷培恩. 上海市嘉定区2018－2020年成蚊生态学监测研究[J]. 中国媒介生物学及控制杂志, 2022, 33(3): 346-350.
[14]	李希尚, 王加志, 李胜国, 汤宗艳, 杨东海, 尹授钦, 王兴娟, 李增助, 蔡文斌. 云南省腾冲市城区2018－2020年蚊虫调查分析[J]. 中国媒介生物学及控制杂志, 2022, 33(3): 356-359.
[15]	李炳辉, 朱海龙, 马小芳, 王伟, 宋富成, 姜洪荣, 孙钦同, 付齐齐. 基于集中度和圆形分布法分析山东省青岛市2017-2020年媒介蚊虫季节性特征[J]. 中国媒介生物学及控制杂志, 2022, 33(2): 230-233.