植物源驱蚊活性单体化合物研究进展

doi:10.11853/j.issn.1003.8280.2023.02.022

摘要/Abstract

摘要： 蚊类是全球公认的危害人类健康的多种传染病的重要媒介，除流行性乙型脑炎和黄热病外，其他蚊媒疾病尚未成功研制出有效疫苗，通过使用驱避剂作为个人的有效防护是减少这些传染病危害的重要措施。传统的化学防治技术正面临着昆虫抗药性和环境污染等问题，植物源单体化合物作为安全绿色环保类的驱避剂是研究热点之一。该文总结了天然活性化合物对蚊虫的驱避活性及发展前景，为科学制定蚊类防治方案和防控新技术的研发提供参考依据。

关键词: 蚊, 驱避, 植物源精油, 活性化合物

Abstract: Mosquitoes are globally recognized as important vectors of many infectious diseases that threaten human health. Effective vaccines have not been successfully developed for most mosquito-borne diseases, except for Japanese encephalitis and yellow fever, and the use of repellents as an effective preventive measure is important for reducing the risk of these diseases. Traditional chemical control agents have the problems of insect resistance and environmental pollution. Botanical monomer compounds as safe and green repellents have become a research hotspot. In this review, we summarize botanical monomeric compounds as mosquito repellents and their repellent activities in categories. The activity and prospect of botanical monomeric compounds as mosquito repellents were summarized in this paper, which provide reference for the scientific formulation of mosquito control programs and the research and development of new control technologies.

Key words: Mosquito, Repellent, Botanical essential oil, Active compounds

中图分类号:

邓婉, 李密, 莫建初. 植物源驱蚊活性单体化合物研究进展[J]. 中国媒介生物学及控制杂志, 2023, 34(2): 276-284.

DENG Wan, LI Mi, MO Jian-chu. Research progress of botanical monomeric compounds as mosquito repellents[J]. Chinese Journal of Vector Biology and Control, 2023, 34(2): 276-284.

参考文献

[1] 刘起勇. 2005-2020年我国媒介生物传染病报告病例:流行趋势、防控挑战及应对策略[J]. 中国媒介生物学及控制杂志,2022,33(1):1-7. DOI:10.11853/j.issn.1003.8280.2022.01.001.Liu QY. Reported cases of vector-borne diseases in China, 2005-2020:Epidemic trend, challenges in prevention and control, and related coping strategies[J]. Chin J Vector Biol Control, 2022,33(1):1-7. DOI:10.11853/j.issn.1003.8280.2022.01.001.(in Chinese)
[2] Benelli G, Wilke ABB, Beier JC. Aedes albopictus (Asian tiger mosquito)[J]. Trends Parasitol, 2020, 36(11):942-943. DOI:10.1016/j.pt.2020.01.001.
[3] Borrego LG, Ramarosandratana N, Jeanneau E, et al. Effect of the stereoselectivity of para-menthane-3, 8-diol isomers on repulsion toward Aedes albopictus[J]. J Agric Food Chem, 2021, 69(37):11095-11109. DOI:10.1021/acs.jafc.1c03897.
[4] Grison C, Carrasco D, Pelissier F, et al. Reflexion on bio-sourced mosquito repellents:Nature, activity, and preparation[J]. Front Ecol Evol,2020,8:8. DOI:10.3389/fevo.2020.00008.
[5] Fernandes MRG, Lopes LC, Iwami RS, et al. Efficacy and safety of repellents marketed in Brazil against bites from Aedes aegypti and Ae albopictus:A systematic review[J]. Travel Med Infect Dis,2021,44:102179. DOI:10.1016/j.tmaid.2021. 102179.
[6] Budiman, Ishak H, Stang, et al. Essential oil as a new tool for larvicidal Aedes aegypti:A systematic review[J]. Gac Sanit, 2021, 35 Suppl 2:S459-462. DOI:10.1016/j.gaceta.2021. 10.074.
[7] da Silva MRM, Ricci-Júnior E. An approach to natural insect repellent formulations:From basic research to technological development[J]. Acta Trop, 2020, 212:105419. DOI:10.1016/j.actatropica.2020.105419.
[8] Islam J, Zaman K, Duarah S, et al. Mosquito repellents:An insight into the chronological perspectives and novel discoveries[J]. Acta Trop,2017,167:216-230. DOI:10.1016/j.actatropica. 2016.12.031.
[9] Tavares M, Da Silva MRM, De Oliveira De Siqueira LB, et al. Trends in insect repellent formulations:A review[J]. Int J Pharmaceut,2018,539(1/2):190-209. DOI:10.1016/j.ijpharm. 2018.01.046.
[10] 刘一婧, 杜丽娜, 金义光. 驱避剂及其剂型的研究进展[J]. 国际药学研究杂志, 2020, 47(12):1104-1112. DOI:10.13220/j.cnki.jipr.2020.12.012.Liu YJ, Du LN, Jin YG. Progress in repellents and their formulations[J]. J Int Pharm Res, 2020, 47(12):1104-1112. DOI:10.13220/j.cnki.jipr.2020.12.012.(in Chinese)
[11] Gnankine O, Bassole IHN. Essential oils as an alternative to pyrethroids' resistance against Anopheles species complex Giles (Diptera:Culicidae)[J]. Molecules,2017,22(10):1321. DOI:10.3390/molecules22101321.
[12] Chen JX, Song BA. Natural nematicidal active compounds:Recent research progress and outlook[J]. J Integr Agric, 2021, 20(8):2015-2031. DOI:10.1016/S2095-3119(21)63617-1.
[13] Faria JMS, Barbosa P, Vieira P, et al. Phytochemicals as biopesticides against the pinewood nematode Bursaphelenchus xylophilus:A review on essential oils and their volatiles[J]. Plants, 2021, 10(12):2614. DOI:10.3390/plants10122614.
[14] Gad HA, Ramadan GRM, El-Bakry AM, et al. Monoterpenes:Promising natural products for public health insect control:A review[J]. Int J Trop Insect Sci, 2022, 42(2):1059-1075. DOI:10.1007/s42690-021-00692-4.
[15] de Oliveira MAS, Coutinho HDM, de Lacerda Neto LJ, et al. Repellent activity of essential oils against Culicids:A review[J]. Sustain Chem Pharm, 2020, 18:100328. DOI:10.1016/j.scp.2020.100328.
[16] Chellappandian M, Vasantha-Srinivasan P, Senthil-Nathan S, et al. Botanical essential oils and uses as mosquitocides and repellents against dengue[J]. Environ Int, 2018, 113:214-230. DOI:10.1016/j.envint.2017.12.038.
[17] Asadollahi A, Khoobdel M, Zahraei-Ramazani A, et al. Effectiveness of plant-based repellents against different Anopheles species:A systematic review[J]. Malar J, 2019, 18:436. DOI:10.1186/s12936-019-3064-8.
[18] de Souza MA, da Silva L, Macêdo MJF, et al. Adulticide and repellent activity of essential oils against Aedes aegypti (Diptera:Culicidae)-a review[J]. South African J Bot, 2019, 124:160-165. DOI:10.1016/j.sajb.2019.05.007.
[19] Silverio MRS, Espindola LS, Lopes NP, et al. Plant natural products for the control of Aedes aegypti: The main vector of important arboviruses[J]. Molecules, 2020, 25(15):3484. DOI:10.3390/molecules25153484.
[20] Spinozzi E, Maggi F, Bonacucina G, et al. Apiaceae essential oils and their constituents as insecticides against mosquitoes:A review[J]. Ind Crops Prod, 2021, 171:113892. DOI:10.1016/j.indcrop.2021.113892.
[21] Misni N, Nor ZM, Ahmad R, et al. Microencapsulation preservation of the stability and efficacy of Citrus grandis oil:Based repellent formulation against Aedes aegypti during storage[J]. Molecules, 2021, 26(12):3599. DOI:10.3390/molecules 26123599.
[22] Campos EVR, de Oliveira JL, Abrantes DC, et al. Recent developments in nanotechnology for detection and control of Aedes aegypti-borne diseases[J]. Front Bioeng Biotechnol, 2020, 8:102. DOI:10.3389/fbioe.2020.00102.
[23] 郝蕙玲, 代浩. 植物精油在卫生杀虫中的应用与挑战[J]. 中华卫生杀虫药械, 2019, 25(3):284-288. DOI:10.19821/j.1671-2781.2019.03.025.Hao HL, Dai H. Application and challenges of plant essential oils in health pest control[J]. Chin J Hyg Insect Equip, 2019, 25(3):284-288. DOI:10.19821/j.1671-2781.2019.03.025.
[24] Esmaili F, Sanei-Dehkordi A, Amoozegar F, et al. A review on the use of essential oil-based nanoformulations in control of mosquitoes[J]. Biointerface Res Appl Chem, 2021, 11(5):12516-12529. DOI:10.33263/briac115.1251612529.
[25] 张亚平. 无花果驱虫成分提取及其构效关系研究[D]. 杭州:浙江大学, 2016.Zhang YP. Reasearch on the extraction and structure-activity relationship of insect repellent ingredients from Ficus carica L.[D]. Hangzhou:Zhejiang University, 2016. (in Chinese)
[26] 徐士超, 董欢欢, 曾小静, 等. 萜类植物源农药的筛选及活性研究进展[J]. 林产化学与工业, 2019, 39(1):1-12. DOI:10.3969/j.issn.0253-2417.2019.01.001.Xu SC, Dong HH, Zeng XJ, et al. Research progress in screening and bioactivity of terpenoid botanical pesticides[J]. Chem Ind Forest Prod, 2019, 39(1):1-12. DOI:10.3969/j.issn.0253-2417.2019.01.001.(in Chinese)
[27] Benelli G, Maggi F, Pavela R, et al. Mosquito control with green nanopesticides:Towards the one health approach? A review of non-target effects[J]. Environ Sci Pollut Res, 2018, 25(11):10184-10206. DOI:10.1007/s11356-017-9752-4.
[28] Benelli G, Mehlhorn H. Mosquito-borne diseases:Implications for public health[M]. Cham:Springer, 2018:69-130. DOI:10.1007/978-3-319-94075-5.
[29] 肖崇厚. 中药化学[M]. 上海:上海科学技术出版社, 1997:422-494.Xiao CH. Chinese medicine chemistry[M]. Shanghai:Shanghai Publisher of Science and Technology, 1997:422-494. (in Chinese)
[30] Bedini S, Flamini G, Cosci F, et al. Cannabis sativa and Humulus lupulus essential oils as novel control tools against the invasive mosquito Aedes albopictus and fresh water snail Physella acuta[J]. Ind Crops Prod, 2016, 85:318-323. DOI:10.1016/j.indcrop.2016.03.008.
[31] Liakakou A, Angelis A, Papachristos DP, et al. Isolation of volatile compounds with repellent properties against Aedes albopictus (Diptera:Culicidae) using CPC technology[J]. Molecules, 2021, 26(11):3072. DOI:10.3390/molecules 26113072.
[32] 姚新生. 天然药物化学[M]. 2版. 北京:人民卫生出版社, 1994:276-323.Yao XS. Natural medicinal chemistry[M]. 2nd ed. Beijing:People's Sanitary Publishing Press, 1994:276-323. (in Chinese)
[33] Dube FF, Tadesse K, Birgersson G, et al. Fresh, dried or smoked? Repellent properties of volatiles emitted from ethnomedicinal plant leaves against malaria and yellow fever vectors in Ethiopia[J]. Malar J, 2011, 10(1):375. DOI:10.1186/1475-2875-10-375.
[34] Ross PA, Nematollahi N, Steinemann A, et al. Differential toxicological effects of natural and synthetic sources and enantiomeric forms of limonene on mosquito larvae[J]. Air Qual Atmos Health, 2022, 15(1):31-34. DOI:10.1007/s11869-021-01106-7.
[35] Sanei-Dehkordi A, Moemenbellah-Fard MD, Saffari M, et al. Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors[J]. BMC Complement Med Ther, 2022, 22(1):140. DOI:10.1186/s12906-022-03624-y.
[36] Evergetis E, Michaelakis A, Haroutounian SA. Exploitation of Apiaceae family essential oils as potent biopesticides and rich source of phellandrenes[J]. Ind Crops Prod, 2013, 41:365-370. DOI:10.1016/j.indcrop.2012.04.058.
[37] Park BS, Choi WS, Kim JH, et al. Monoterpenes from thyme (Thymus vulgaris) as potential mosquito repellents[J]. J Am Mosq Control Assoc, 2005, 21(1):80-83. DOI:10.2987/8756-971X(2005)21[80:MFTTVA]2.0.CO;2.
[38] 胡建华, 韩嘉, 李倩茹, 等. α-蒎烯衍生物的合成及其综合利用[J]. 山东化工, 2014, 43(6):64-68. DOI:10.3969/j.issn. 1008-021X.2014.06.022.Hu JH, Han J, Li QR, et al. Synthesis and comprehensive utilization of α-pinene derivatives[J]. Shandong Chem Ind, 2014, 43(6):64-68. DOI:10.3969/j.issn.1008-021X.2014.06.022.(in Chinese)
[39] 刘禺卿. 银灰菊精油周年变化及灭蚊驱蚊效果研究[D]. 上海:上海交通大学, 2008.Liu YQ. Study on annual changes of santolina essential oil and its biological activity against mosquitoes[D]. Shanghai:Shanghai Jiaotong University, 2008. (in Chinese)
[40] Chen W, Viljoen AM. Geraniol-a review of a commercially important fragrance material[J]. South African J Bot, 2010, 76(4):643-651. DOI:10.1016/j.sajb.2010.05.008.
[41] Wong C, Corona C, Coats J. Chapter 3:Biorational compounds as effective arthropod repellents against mosquitoes and ticks[M]//Corona C, Debboun M, Coats J. Advances in arthropod repellents. Academic Press, 2022:33-48. DOI:10.1016/B978-0-323-85411-5.00012-1.
[42] Nesterkina M, Bernier UR, Tabanca N, et al. Repellent activity of monoterpenoid esters with neurotransmitter amino acids against yellow fever mosquito, Aedes aegypti[J]. Open Chem, 2018, 16(1):95-98. DOI:10.1515/chem-2018-0015.
[43] Li MX, Ma YP, Zhang HX, et al. Repellent, larvicidal and adulticidal activities of essential oil from Dai medicinal plant Zingiber cassumunar against Aedes albopictus[J]. Plant Divers, 2021, 43(4):317-323. DOI:10.1016/j.pld.2020.11.008.
[44] Sales A, de Oliveira Felipe L, Bicas JL. Production, properties, and applications of α-terpineol[J]. Food Bioprocess Technol, 2020, 13(8):1261-1279. DOI:10.1007/s11947-020-02461-6.
[45] Traboulsi AF, El-Haj S, Tueni M, et al. Repellency and toxicity of aromatic plant extracts against the mosquito Culex pipiens molestus (Diptera:Culicidae)[J]. Pest Manage Sci, 2005, 61(6):597-604. DOI:10.1002/ps.1017.
[46] Weldon PJ, Carroll JF, Kramer M, et al. Anointing chemicals and hematophagous Arthropods:Responses by ticks and mosquitoes to citrus (Rutaceae) peel exudates and monoterpene components[J]. J Chem Ecol, 2011, 37(4):348-359. DOI:10.1007/s10886-011-9922-7.
[47] Omolo MO, Okinyo D, Ndiege IO, et al. Repellency of essential oils of some Kenyan plants against Anopheles gambiae[J]. Phytochemistry, 2004, 65(20):2797-2802. DOI:10.1016/j.phytochem.2004.08.035.
[48] Carroll JF, Demirci B, Kramer M, et al. Repellency of the Origanum onites L. essential oil and constituents to the lone star tick and yellow fever mosquito[J]. Nat Prod Res, 2017, 31(18):2192-2197. DOI:10.1080/14786419.2017.1280485.
[49] Ma YP, Li MX, Zhang HX, et al. Bioassay-guided isolation of active compounds from Adenosma buchneroides essential oil as mosquito repellent against Aedes albopictus[J]. J Ethnopharmacol, 2019, 231:386-393. DOI:10.1016/j.jep. 2018.11.031.
[50] Michaelakis A, Vidali VP, Papachristos DP, et al. Bioefficacy of acyclic monoterpenes and their saturated derivatives against the West Nile vector Culex pipiens[J]. Chemosphere, 2014, 96:74-80. DOI:10.1016/j.chemosphere.2013.07.032.
[51] Innocent E, Joseph CC, Gikonyo NK, et al. Constituents of the essential oil of Suregada zanzibariensis leaves are repellent to the mosquito, Anopheles gambiae s. s[J]. J Insect Sci, 2010, 10(1):57. DOI:10.1673/031.010.5701.
[52] Gillij YG, Gleiser RM, Zygadlo JA. Mosquito repellent activity of essential oils of aromatic plants growing in Argentina[J]. Bioresource Technol, 2008, 99(7):2507-2515. DOI:10.1016/j.biortech.2007.04.066.
[53] Reichert W, Ejercito J, Guda T, et al. Repellency assessment of Nepeta cataria essential oils and isolated nepetalactones on Aedes aegypti[J]. Sci Rep, 2019, 9(1):1524. DOI:10.1038/s41598-018-36814-1.
[54] Liu F, Wang Q, Xu P, et al. A dual-target molecular mechanism of pyrethrum repellency against mosquitoes[J]. Nat Commun, 2021, 12(1):2553. DOI:10.1038/s41467-021-22847-0.
[55] Haris A, Azeem M, Binyameen M. Mosquito repellent potential of Carpesium abrotanoides essential oil and its main components against a dengue vector, Aedes aegypti (Diptera:Culicidae)[J]. J Med Entomol, 2022, 59(3):801-809. DOI:10.1093/jme/tjac009.
[56] Demirci B, Tsikolia M, Bernier UR, et al. Phoenix dactylifera L. spathe essential oil:Chemical composition and repellent activity against the yellow fever mosquito[J]. Acta Trop, 2013, 128(3):557-560. DOI:10.1016/j.actatropica.2013.08.003.
[57] Paluch G, Grodnitzky J, Bartholomay L, et al. Quantitative structure-activity relationship of botanical sesquiterpenes:Spatial and contact repellency to the yellow fever mosquito, Aedes aegypti[J]. J Agric Food Chem, 2009, 57(16):7618-7625. DOI:10.1021/jf900964e.
[58] Ali A, Radwan MM, Wanas AS, et al. Repellent activity of carrot seed essential oil and its pure compound, carotol, against mosquitoes[J]. J Am Mosq Control Assoc, 2018, 34(4):272-280. DOI:10.2987/18-6751.1.
[59] Clarkson TC, Janich AJ, Sanchez-Vargas I, et al. Nootkatone is an effective repellent against Aedes aegypti and Ae. albopictus[J]. Insects,2021,12(5):386. DOI:10.3390/insects12050386.
[60] Inocente EA, Shaya M, Acosta N, et al. A natural agonist of mosquito TRPA1 from the medicinal plant Cinnamosma fragrans that is toxic, antifeedant, and repellent to the yellow fever mosquito Aedes aegypti[J]. PLoS Negl Trop Dis, 2018, 12(2):e0006265. DOI:10.1371/journal.pntd.0006265.
[61] Nararak J, Di Giorgio C, Sukkanon C, et al. Excito-repellency and biological safety of β-caryophyllene oxide against Aedes albopictus and Anopheles dirus (Diptera:Culicidae)[J]. Acta Trop, 2020, 210:105556. DOI:10.1016/j.actatropica.2020. 105556.
[62] Gokulakrishnan J, Kuppusamy E, Shanmugam D, et al. Pupicidal and repellent activities of Pogostemon cablin essential oil chemical compounds against medically important human vector mosquitoes[J]. Asian Pac J Trop Dis, 2013, 3(1):26-31. DOI:10.1016/S2222-1808(13)60006-7.
[63] Odalo JO, Omolo MO, Malebo H, et al. Repellency of essential oils of some plants from the Kenyan coast against Anopheles gambiae[J]. Acta Trop, 2005, 95(3):210-218. DOI:10.1016/j.actatropica.2005.06.007.
[64] Kang SH, Kim MK, Seo DK, et al. Comparative repellency of essential oils against Culex pipiens pallens (Diptera:Culicidae)[J]. J Korean Soc Appl Biol Chem, 2009, 52(4):353-359. DOI:10.3839/jksabc.2009.063.
[65] Chokechaijaroenporn O, Bunyapraphatsara N, Kongchuensin S. Mosquito repellent activities of Ocimum volatile oils[J]. Phytomedicine, 1994, 1(2):135-139. DOI:10.1016/S0944-7113(11)80031-0.
[66] Wang DL, Ma WB, Jia MC, et al. pHEMA hydrogels with pendant triazinyl-β-cyclodextrin as an efficient and recyclable reservoir for loading and release of plant-based mosquito repellents:A new aqueous mosquito repellent formulation[J]. RSC Adv, 2016, 6(33):27301-27312. DOI:10.1039/C5RA27942A.
[67] Ajmal L, Hamid A, Raza FA, et al. Repellent activity of trans-anethole and tea tree oil against Aedes aegypti and their interaction with OBP1, a protein involved in olfaction[J]. Entomol Exp Appl, 2022, 170(7):547-554. DOI:10.1111/eea.13179.
[68] Nguyen QBD, Vu MAN, Hebert AA. Insect repellents:An updated review for the clinician[J]. J Am Acad Dermatol, 2023, 88(1):123-130. DOI:10.1016/j.jaad.2018.10.053.
[69] Kim SI, Tak JH, Seo JK, et al. Repellency of veratraldehyde (3, 4-dimethoxy benzaldehyde) against mosquito females and tick nymphs[J]. Appl Sci, 2021, 11:4861. DOI:10.3390/app11114861.
[70] Xu PX, Choo YM, de La Rosa A, et al. Mosquito odorant receptor for DEET and methyl jasmonate[J]. Proc Natl Acad Sci USA, 2014, 111(46):16592-16597. DOI:10.1073/pnas. 1417244111.
[71] Tauxe CM, MacWilliam D, Boyle SM, et al. Targeting a dual detector of skin and CO₂ to modify mosquito host seeking[J]. Cell,2013,155(6):1365-1379. DOI:10.1016/j.cell.2013. 11.013.
[72] Xu PX, Choo YM, An S, et al. Mosquito odorant receptor sensitive to natural spatial repellents and inhibitory compounds[J]. Insect Biochem Mol Biol, 2022, 144:103763. DOI:10. 1016/j.ibmb.2022.103763.
[73] Zhu JJ, Cermak SC, Kenar JA, et al. Better than DEET repellent compounds derived from coconut oil[J]. Sci Rep, 2018, 8(1):14053. DOI:10.1038/s41598-018-32373-7.
[74] Tabanca N, Gao ZP, Demirci B, et al. Molecular and phytochemical investigation of Angelica dahurica and A. pubescentis essential oils and their biological activity against Aedes aegypti, Stephanitis pyrioides, and Colletotrichum species[J]. J Agric Food Chem, 2014, 62(35):8848-8857. DOI:10.1021/jf5024752.
[75] 邓婉. 植物精油对白纹伊蚊和埃及伊蚊的驱避效果研究[D]. 杭州:浙江大学, 2015.Deng W. The study of plant essential oil as mosquito repellents against Aedes albopictus Skuse and Ae. aegypti Linnaeus[D]. Hangzhou:Zhejiang University, 2015. (in Chinese)