乙酰胆碱酯酶基因突变与蚊虫抗药性关系的研究进展

doi:10.11853/j.issn.1003.8280.2017.06.026

中国媒介生物学及控制杂志 ›› 2017, Vol. 28 ›› Issue (6): 608-611.DOI: 10.11853/j.issn.1003.8280.2017.06.026

乙酰胆碱酯酶基因突变与蚊虫抗药性关系的研究进展

陆靖¹, 程鹏², 公茂庆², 沈波³, 朱昌亮³, 崔文⁴, 谭文彬⁵

1 济南大学山东省医学科学院医学与生命科学学院, 济南 250001;
2 山东省寄生虫病防治研究所, 山东济宁 272033;
3 南京医科大学, 南京 211166;
4 济宁医学院司法鉴定中心, 山东济宁 272067;
5 济宁医学院基础医学院, 山东济宁 272067

收稿日期:2017-06-25 出版日期:2017-12-20 发布日期:2017-12-20
通讯作者: 谭文彬,Email:1392144@163.com
作者简介:陆靖,女,在读硕士,主要从事病原生物学研究,Email:18766888418@163.com
基金资助:
国家自然科学基金（81271876，81471985，81672059）；山东省自然科学基金（ZR2015YL023）；山东省高等学校科技发展计划（J13LK12）；山东省高等学校青年骨干教师国内访问学者项目；山东省高校优秀科研创新团队计划

Advances in studies of acetylcholinesterase gene mutations associated with insecticide resistance in mosquitoes

LU Jing¹, CHENG Peng², GONG Mao-qing², SHEN Bo³, ZHU Chang-liang³, CUI Wen⁴, TAN Wen-bin⁵

1 School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250001, Shandong Province, China;
2 Shandong Institute of Parasitic Diseases;
3 Nanjing Medical University;
4 Center of Forensic Science of Jining Medical University;
5 Academy of Basic Medicine, Jining Medical University

Received:2017-06-25 Online:2017-12-20 Published:2017-12-20
Supported by:
Supported by the Natural Science Foundation of China(No. 81271876, 81471985, 81672059), the Natural Science Foundation of Shandong Province of China(No. ZR2015YL023), Shandong Province Higher Educational Science and Technology Program(No. J13LK12), Program of Domestic Study for Young Scholar of University in Shandong Province Sponsored by Shandong Provincial Educational Department, and the Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province

摘要/Abstract

摘要： 大量使用有机磷和氨基甲酸酯类杀虫剂可导致蚊虫产生显著抗药性。抗性产生的重要原因之一是乙酰胆碱酯酶（AChE）对杀虫剂的敏感性下降，而根本原因是AChE基因突变。该文对AChE基因的结构特点、功能、活性位点及AChE基因改变与蚊虫抗药性关系的研究进行归纳概述，并对蚊虫AChE基因研究前景进行分析和展望。

关键词: 蚊虫, 抗药性, 乙酰胆碱酯酶, 基因突变

Abstract: Intensive use of organophosphate and carbamate insecticides has led to the development of resistance in mosquitoes. Acetylcholinesterase (AChE)insensitivity to organophosphate and carbamate insecticides has been identified as a major resistance mechanism in mosquitoes. This paper reviewed the progress of AChE gene mutations associated with insecticide resistance in mosquitoes. The AChE structure characteristics, the functional sites of AChE genes and the effect of mutation on insecticide resistance were detailed. Finally, the prospects in the studies of mosquito AChE were analyzed.

Key words: Mosquitoes, Insecticide resistance, Acetylcholinesterase, Gene mutation

中图分类号:

陆靖, 程鹏, 公茂庆, 沈波, 朱昌亮, 崔文, 谭文彬. 乙酰胆碱酯酶基因突变与蚊虫抗药性关系的研究进展[J]. 中国媒介生物学及控制杂志, 2017, 28(6): 608-611.

LU Jing, CHENG Peng, GONG Mao-qing, SHEN Bo, ZHU Chang-liang, CUI Wen, TAN Wen-bin. Advances in studies of acetylcholinesterase gene mutations associated with insecticide resistance in mosquitoes[J]. Chines Journal of Vector Biology and Control, 2017, 28(6): 608-611.

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乙酰胆碱酯酶基因突变与蚊虫抗药性关系的研究进展

Advances in studies of acetylcholinesterase gene mutations associated with insecticide resistance in mosquitoes

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