基于昆虫共生菌沃尔巴克氏体的蚊媒和蚊媒病控制研究进展

doi:10.11853/j.issn.1003.4692.2014.01.001

中国媒介生物学及控制杂志 ›› 2014, Vol. 25 ›› Issue (1): 1-7.DOI: 10.11853/j.issn.1003.4692.2014.01.001

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基于昆虫共生菌沃尔巴克氏体的蚊媒和蚊媒病控制研究进展

潘晓玲¹,刘起勇^2,3,奚志勇^1,4

1美国密歇根州立大学微生物学和分子遗传学系,密歇根东兰辛 48824;
2中国疾病预防控制中心传染病预防控制所媒介生物控制室,传染病预防控制国家重点实验室;
3世界卫生组织媒介生物监测与管理合作中心;
4 中山大学-密歇根州立大学热带病虫媒控制联合研究中心

收稿日期:2014-01-07 出版日期:2014-02-20 发布日期:2014-02-20
作者简介:潘晓玲, 女, 博士, 从事感染沃尔巴克氏体的蚊虫宿主的抗病毒分子机制研究。Email: xpan@msu.edu
基金资助:
教育部科学技术研究重点(重大)项目(311030); 广东省引进创新科研团队计划(2011S009 ); 广州开发区科技领军人才项目(2013L-P116); 美国国立卫生研究院和盖茨全球健康大挑战联合基金; 美国国立卫生研究院/国家过敏症与传染病研究所基金(R01 AI-080597)

Advance in developing Wolbachia as a mean to control mosquitoand mosquito borne diseases

PAN Xiao-ling¹, LIU Qi-yong^2,3, XI Zhi-yong^1,4

1 Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, 48824, USA;
2 State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Controland Prevention, Chinese Center for Disease Control and Prevention;
3 WHO Collaborating Center for Vector Surveillanceand Management;
4 Sun Yat-sen University-Michigan State University Joint Center of Vector Control for Tropical Diseases

Received:2014-01-07 Online:2014-02-20 Published:2014-02-20
Supported by:
Supported by the Key Project of Chinese Ministry of Education (No. 311030), Guangdong Innovative Research Team Program(No. 2011S009), Scientific and Technological Leading Talents of Guangzhou Development District (No. 2013L-P116), a grant from the Foundation for the NIH through the Grand Challenges in Global Health Initiative of the Bill and Melinda Gates Foundation, a grant (No. R01 AI-080597) from the National Institutes of Health/National Institute for Allergy and Infectious Disease

摘要/Abstract

摘要：

沃尔巴克氏体(Wolbachia)是一种在自然界节肢动物体内广泛存在、能经卵传递的革兰阴性胞内共生菌。估计约65%的昆虫种类和28%的蚊虫种类天然携带沃尔巴克氏体。当携带沃尔巴克氏体的雄蚊与不携带或者携带不同沃尔巴克氏体型的雌蚊交配,雌蚊产的卵将不会孵化,该性状称为胞质不相容性(cytoplasmic incompatibility,CI)。胞质不相容性赋予携带沃尔巴克氏体的雌蚊生殖优势,从而使其可以扩散到蚊群中去;同时沃尔巴克氏体在蚊媒体内能对多种人类病原体(如登革热病毒、黄病毒和疟原虫等)产生抗性。基于以上特性可建立2种虫媒病控制的新策略:①将野生的传病蚊媒改变成对人类病原体具有抗性的蚊虫,从而阻断蚊媒病的传播(种群替换);②持续诱导引起胞质不相容性的交配,从而压制或区域性根除传病蚊媒(种群压制)。

关键词: 沃尔巴克氏体, 胞质不相容性, 种群压制, 种群替换

Abstract:

Wolbachia spp. are maternally transmitted Gram-negative endosymbiotic bacteria. With infection occurring in a wide range of invertebrates, Wolbachia is estimated to infect 65% of insect species and 28% of mosquito species in nature. An early embryo death, a phenotype referred to as cytoplasmic incompatibility (CI), will occur when infected males mate with uninfected females, or females that carry different type of Wolbachia. CI provides reproductive advantage to infected females, resulting in spread of Wolbachia into mosquito population. Furthermore, Wolbachia can confer mosquito resistant to a variety of human pathogens, including dengue virus, yellow fever virus and malaria parasites. This has led to large efforts to develop Wolbachia-based vector control strategies. One is referred to as population replacement, in which a disease susceptible wild type vector population is modified into a disease resistant population, resulting in blocking of disease transmission. Another is population suppression, in which CI mating is induced in the target population, resulting in suppression, or even eradication of a vector population.

Key words: Wolbachia, Cytoplasmic incompatibility, Population suppression, Population replacement

中图分类号:

潘晓玲,刘起勇,奚志勇. 基于昆虫共生菌沃尔巴克氏体的蚊媒和蚊媒病控制研究进展[J]. 中国媒介生物学及控制杂志, 2014, 25(1): 1-7.

PAN Xiao-ling, LIU Qi-yong, XI Zhi-yong. Advance in developing Wolbachia as a mean to control mosquitoand mosquito borne diseases[J]. Chines Journal of Vector Biology and Control, 2014, 25(1): 1-7.

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基于昆虫共生菌沃尔巴克氏体的蚊媒和蚊媒病控制研究进展

Advance in developing Wolbachia as a mean to control mosquitoand mosquito borne diseases

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