登革热病毒感染标志物检测进展

摘要/Abstract

摘要：

登革热病毒属黄病毒科黄病毒属,为单正链RNA病毒,根据包膜蛋白E抗原性不同分为4 个血清型。主要通过埃及伊蚊和白纹伊蚊传播,引起登革热、登革出血热和登革休克综合征。主要分布在热带和亚热带,影响到全球100多个国家和地区,有25亿人生活在受威胁地区。该文对近年来登革热病毒培养、登革热病毒抗原、抗登革热病毒抗体、登革热病毒非结构蛋白、登革热病毒核酸检测技术研究进展进行综述。结果表明,登革热病毒感染标志物检测,尤其是快速诊断,应以核酸和/或非结构蛋白1检测、特异性抗体检测联合进行较为合适。

关键词: 登革热病毒, 标志物, 检测进展

Abstract:

Dengue virus is a positive-sense RNA virus belonging to the Flavivirus genus of the family Flaviviridae. The virus is classified into four different serotypes based on the antigenicity of its envelope protein E. Mainly transmitted by Aedes aegypti or Aedes albopictus, it causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome, mostly in tropical and subtropical areas. Dengue virus is distributed in more than 100 countries, a threat to the health of 2.5 billion people. This review provides a summary of recent studies on viral culture and detection techniques of the antigen, antibody, nonstructural proteins and nucleic acid. Evidence shows that marker detection, particularly rapid diagnosis, should include nucleic acid and/or nonstructural protein 1 test in combination with specific antibody assay.

Key words: Dengue virus, Markers, Advances in detection techniques

中图分类号:

R373.3⁺3

何金林. 登革热病毒感染标志物检测进展[J]. 中国媒介生物学及控制杂志, 2011, 22(5): 509-511.

HE Jin-lin. Advances in detection markers for Dengue virus[J]. Chines Journal of Vector Biology and Control, 2011, 22(5): 509-511.

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