鼠疫噬菌体研究概述

摘要/Abstract

摘要：

鼠疫噬菌体是一种特异性很强的鼠疫耶尔森菌（Yersinia pestis，鼠疫菌）的细菌病毒，一直被用来进行鼠疫病原体的鉴定。鼠疫噬菌体的早期研究主要以如何在自然界分离、生物学特性、诊断和治疗鼠疫，近年来，随着微生物基因组和蛋白质组学技术的发展，揭示了鼠疫噬菌体在鼠疫菌进化过程中所发生的作用。现就鼠疫噬菌体的研究进展，尤其是基因组的结构、与宿主菌在致病和免疫相关研究做一些介绍，为研发新型分子生物学技术和鼠疫治疗药物提供帮助。

关键词: 鼠疫噬菌体, 基因组, 鼠疫

Abstract:

Yersinia pestis bacteriophage, a strongly specific bacterial virus, is commonly used for identification of the plague pathogen. Early research on this bacteriophage has focused mainly on the natural isolation, biological characteristics, and diagnostic or therapeutic applications. In recent years, advances in microbial genomics and proteomics have shed light on the role of this bacteriophage in the evolution of Y. pestis. This paper summarizes recent progress in Y. pestis bacteriophage research regarding genome structure and related pathogenicity and immunology, for the development of new molecular-based diagnostic modalities and medicines.

Key words: Yersinia pestis bacteriophage, Genome, Plague

中图分类号:

R254.8

王梅, 海荣. 鼠疫噬菌体研究概述[J]. 中国媒介生物学及控制杂志, 2011, 22(3): 297-300.

WANG Mei, HAI Rong. Overview of research on Yersinia pestis bacteriophage[J]. Chines Journal of Vector Biology and Control, 2011, 22(3): 297-300.

参考文献

[1] Sulakvelidzea A, Alavidze Z, Morris JG Jr. Bacteriophage therapy
[J]. Antimicrob Agents Chemother,2001,45(3):649-659.

[2] DabrowskaK,Switala-Jelen K,Opolski A,etal.Bacteriophage penetration in vertebrates
[J]. J Appl Microbiol,2005,98(1):7-13.

[3] Lazarus AS,Gunnison JB. The action of Pasteurella pestis bacterioph ageonstrains of Pasteurella,Salmonella,and Shigella
[J]. Bacteriol,1947,53(6):705-714.

[4] Garcia E, Elliott JM, Ramanculv E, et al. The genome sequence of phiA1122 reveals an intimate history with the coliphage T3 and T7 genomes
[J]. J Bacteriol,2003,185(17):5248-5262.

[5] Zhao X, Wu W, Qi Z,et al. The completegenomesequenceand proteomics of Yersinia pestis phage Yep-phi
[J]. J Gen Virol,2011, 92(Pt 1):216-221.

[6] Schwudke D,Ergin A,Michael K,et al. Broad-Host-RangeYersinia phage PY100: genome sequence, proteome analysis of virions, and DNA packaging strategy
[J]. J Bacteriol,2008,190(1):332-342.

[7] Garcia E, Chain P, Elliott JM, et al.Molecularcharacterization of L-413C, a P2-related plague diagnostic bacteriophage
[J]. Virology,2008,372(1):85-96.

[8] 张涛,冯志勇, 邱俊荣. 鼠疫高级细菌学
[M]. 银川:宁夏人民出版社,2006:99-106.

[9] 王玉梅,白万翔. 鼠疫防治与应急处理指南
[M]. 北京:中国社会出版社,2007:161-163.

[10] Harrison DN, Cavanaugh DC, Rust Jr JH, et al.Characteristicsof a bacteriophage-infected strain of Pasteurella pestis isolated from a human case of plague
[J]. Infect Immun,1971,4(1):85-87.

[11] 赵飞,徐菲莉,海啸. 鼠疫噬菌体对氯仿的敏感性
[J]. 地方病通报,1987,2(4):52-55.

[12] Zhilenkov YL, Fomchenkov VM, Novikov IA, et al. Examining the interaction of phages with microorganisms by fluorometry and electron-orientation spectroscopy
[J]. Vestn Ross Akad Med Nauk,1999(12):24-29.

[13] Novosel’tsev NN, Marchenkov VI. Yersiniapestisphageofanew serovar
[J]. Zh Mikrobiol Epidemiol Immunobiol,1990(11):9-12.

[14] Novosel’tsev NN, Marchenkov VI, Aurutiunov Y. Phages of the Ⅳserovar of Yersinia pestis
[J]. Zh Mikrobiol Epidemiol Immunobiol,1994(6):9-10.

[15] LazarusAS, GunnisonJB.The actionofPasteurellapestis bacteriophage on strains of Pasteurella, Salmonella, and Shigella
[J]. J Bacteriol,1947,53(6):705-714.

[16] Gunnison JB, Larson A, Lazarus AS. Rapid differentiation between Pasteurella pestis and Pasteurella pseudotuberculosis by action of bacteriophage
[J]. J Infect Dis,1951,88(3):254-255.

[17] Dennis DT,Gage KL,Gratz N,et al. Plague manual: epidemiology, distribution, surveillance, and control
[M]. Geneva:World Health Organization,1999:140-144.

[18] Demerec M,Fano U. Bacteriophage-resistant mutants in Escherichia coli
[J]. Genetics,1945,30(2):119-136.

[19] 俞东征. 人兽共患传染病学
[M]. 北京:科学出版社,2009:207.

[20] Deng W, Burland V, Plunkett G 3rd, et al. Genome sequence of Yersinia pestis KIM
[J]. J Bacteriol,2002,184(16):4601-4611.

[21] 戴二黑,童宗中,王效义,等. 应用抑制削减杂交技术进行鼠疫耶尔森菌的比较基因组研究
[J]. 中华微生物学和免疫学杂志,2005,25(3):179-182.

[22] 宋亚军,童宗中,王津,等. 鼠疫耶尔森氏菌菌株91001全基因组序列测定及初步分析
[J]. 解放军医学杂志,2004,29(3):192-199.

[23] Song Y, Tong Z, Wang J, etal.Completegenomesequenceof Yersinia pestis strain 91001, an isolate a virulent to human
[J]. DNA Res,2004,11(3):179-197.

[24] Chain PS, Hu P, Malfatti SA, et al . Complete genomesequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen
[J]. J Bacteriol,2006,188(12): 4453-4463.

[25] Derbise A, Chenal-Francisque V, Pouillot F, et al.Ahorizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillus
[J]. Mol Microbiol,2007,63(4):1145-1157.

[26] Chouikha I,Charrier L, Filali S,et al. Insights into the infective properties of Ypfø, the Yersinia pestis filamentous phage
[J]. Virology,2010,407(1):43-52.

[27] GonzalezMD, LichtensteigerCA, CaughlanR, etal.Conserved filamentous prophage in Escherichia coli O18∶K1∶H7 and Yersinia pestis biovar orientalis
[J]. J Bacteriol,2002,184(21):6050-6055.

[28] 董国润,李敬海,段家伟. 用鼠疫噬菌体诱导鼠疫L型菌的研究
[J]. 中国地方病防治杂志,1990,5(4):194-195.

[29] Cavanaugh DC, Quan SF. Rapid identification of Pasteurella pestis: using specific bacteriophage lyophilized on strips of filter paper, a preliminary report
[J]. Am J Clin Pathol,1953,23(6):619-620.

[30] 邹艳波,迟秀娟,赵斌. 鼠疫噬菌体试纸方法的研究
[J]. 中国地方病防治杂志,2008,23(5):331-332.

[31] Schofield DA, Molineux IJ, Westwater C. Diagnostic bioluminescent phage for detection of Yersinia pestis
[J]. J Clin Microbiol,2009,47(12):3887-3894.

[32] Anisimov AP,Amoako KK. Treatment of plague:promising alternatives to antibiotics
[J]. J Med Microbiol,2006,55(Pt 11):1461-1475.

[33] 费来玺,杨子平,任静,等. 鼠疫菌溶源性的检测
[J]. 地方病通报,1986,1(1):42-43.