关键词: 莪术醇, 布氏田鼠, 不育效果

Abstract:

Objective To determine the anti-fertility effect of curcumol baits on Lasiopodomys brandti. Methods The experimental group was fed with baits of 3 doses, 0.1%, 0.2% and 0.4%, respectively, while the control group received nontoxic blanks. The voles freely consumed the baits for 3 consecutive weeks before gross examination, in which the morphology of genital organs was observed, and the organ coefficient calculated. The sperm quality was measured for male animals. Results Curcumol baits were effective anti-fertility agents against both male and female L. brandti. As for female voles, abnormal ovarian development was observed with impaired follicular maturation in the 0.2% and 0.4% dose groups; increased organ coefficient for the uterus was present in each dose group along with uterine edema, the extent of which was positively correlated with the dose administration. As for male animals, intoxicated individuals had lowered sperm motility, concentration and viability in addition to increased risk of sperm malformation, where the most common abnormality was acrosomal loss; their epididymal organ coefficient also declined to a degree positively correlated with the dose. Curcumol did not affect the individual development of either gender. Conclusion While curcumol baits had anti-fertility effects on L. brandti, the duration and recoverability of drug effect should be further studied.

Key words: Curcumol, Lasiopodomys brandti, Antifertility effect