关键词: 复配, 共毒系数, SAS, 数学模型

Abstract:

Objective A computer program was developed based on the internationally recognized statistics analysis system(SAS) to rapidly screen for the optimal synergistic formula for pesticide formulations. Methods Agents A and B were combined in a certain ratio and subject to the determination of toxicity against Tetranychus cinnabarinus and the computer program calculations for fitting the polynomial mathematical model of the co-toxicity coefficient (CTC), the arcsine transformation of the mass fraction. The derivative of the model curve was calculated and the maximum CTC and the optimal formulation ratio were computed. Results The polynomial mathematical model was statistically significant (F＝20.76, P＜0.05), the total coefficient of determination (R2)＝0.9540; the model equation was: CTC＝-2.021 499X2＋222.543 940X－5951.467 969; the derivation of the curve revealed the best extreme value X＝55.04, with the corresponding maximum CTC of 173.42 and the optimal formulation ratio of 2∶1. Conclusion Upon dual verification using program calculations, the established screening method proved to be an accurate, reliable, rapid and user-friendly approach to screen for the optimal synergistic formula.

Key words: Formulation, Co-toxicity coefficient, Statistics analysis system, Mathematical model