关键词: 鼠疫, F1抗体, 流行病调查, 隐性感染

Abstract: Objective To study the three-dimensional distribution and maintenance mechanisms of plague F1 antibody of healthy population in the plague natural foci of Hebei province. Methods To sample 196 blood samples from three administrative villages belonging to plague natural foci formerly, and collect 100 blood samples from non-infected areas as the control. Indirect hemagglutination test(IHA) and colloedal gold immunobinding were used in this test. Results There were 4 positive among 196 blood samples, and the positive rate was 2.04%. There were 4 positive samples in IHA and 3 positive samples in colloedal gold immunobinding. The human serums collected from non-infected areas were all negative after tested by theses two methods. There was significant difference between the positive rate of F1 antibody in epidemic areas and the positive rate of F1 antibody in non-epidemic areas (χ₂=0.822,P<0.05). Conclusion At present, there are still a number of F1 antibody positive population in the natural epidemic focus of Hebei, and it needs further investigation and analysis to clarify.