关键词: 肾综合征出血热, 双价肾综合征出血热灭活疫苗, 防病效果

Abstract: Objective To evaluate the immunization effect of hemorrhagic fever with renal syndrome(HFRS) (Type Ⅰ+Ⅱ) bi-value vaccine. Methods Choose the high-endemic areas as trial filed and the permanent dwellers aging from 16 to 60 as inoculability population, and request the immunization coverage rate exceeds 70%. Test the change of IgG antibody level after vaccination with IFA, and to understand the condition of seroconversionrate. Observe the control efficacy of vaccination intervention to HFRS. Results (1) Coverage rate: inoculability population aging 16 to 60 was theoretically 29 088, and the actual population only reached 22 821. The coverage rate was 78.46%, highest in Luannan county (90.37%) and lowest in Funing county (73.39%). It was 80.29%, 74.19% and 75.57% in Luanxian, Lulong and Qinglong, respectively. (2) Positive rate of IgG antibody: the average positive rate of pre-immune was 3.33%, and it was 80.63% after immune. Test the antibody before and after immunization for the same group, and it was 2.62% before immunization and was 80.63% after immune. (3) Incidence rate: there were 9 cases in the high-endemic areas after immunization and incidence rate was 18.79/100 million. There were 80 cases before immunization and incidence rate was 166.56/100 million. Conclusion The control effect was prominent when people immunized with HFRS (Type Ⅰ+Ⅱ) bi-value vaccine and the coverage rate reaches 70% in high-endemic areas, which can be expanded in the whole province.