关键词: 黑线姬鼠, 杀鼠灵, 抗药性, 检测

Abstract: Objective To test the resistance to warfarin by the striped field mouse (Apodemus agrarius) captured from Shunyi district of Beijing. Methods 33 mice were given the bait which contained 0.02% warfarin in 6 consecutive days with no-choice way in laboratory. Results The warfarin bait caused 63.64% mortality, the average ingestion of poison of dead mice was (76.91±34.76)mg/kg and the average lethal time was (7.23±2.51)d. The resistant percentage was 36.36% and the average ingestion of poison of survival individuals was (106.79±26.68)mg/kg. Conclusion (1) The striped field mouse from Shunyi district has become resistant to warfarin after 20 years’ application of the second generation of anticoagulant rodenticides, which resulted in the resistant group;(2) The female mouse has broader sensitivity range than the male one; the juvenile and old group have higher resistance than adult and sub-adult ones. It is suggested that the no-choice of six-day feeding resistance test program is suitable for monitoring the resistance to anticoagulant rodenticides by rodents and integrative methods are necessary to reduce resistance of rodents and to prolong the time of using anticoagulant rodenticides.