关键词: 肾综合征出血热, 监测, 发病率, 带病毒率

Abstract: Objective To understand the epidemic dynamic of hemorrhagic fever with renal syndrome(HFRS) which was in humans and animals in Taizhou city for preventive measures against the disease.Methods Choose the surveillant aera of Tiantai and Xianju,and the epidemic foci of the other counties as surveillance of epidemic of HFRS in humans and host animal,and use the indirect immunofluorescence assay to determine the antiboby and direct immunofluorescence assay to determine the antigen. Results 13 752 cases had been reported from 1984 to 2005 in Taizhou city,and the annual incidence was 11.90/100 000.The incidence 34.85/100 000 of 1986 was the highest.The incidence and the number of cases of Tiantai county was the highest in Taizhou city.From November to January of the next year was the main onset peak,and from April to June also had a small onset peak.The onset curve showed a double peak mode.The incidence number of age group of 20 to 49 accounted for 66.57% and the ratio of the male to female was 2.58∶1.Farmers accounted for 80.95% of all patients.The accordant rate of the suspected patients and the confirmed patients was 68.72%,and the recessive infection rate of in healthy people was 3.13%. The total density of small animal was 10.94%,and the outdoor density was 13.07% which was obviously higher than that in residential area 8.79%(P<0.01).Apodemus agrarius which accounted for 76.89%.However,the dominant species of rodents at residential the distribution of specific group was 2 items and 16 kinds in all.The predominant species of rodents outdoors was Rattus norvegicus Berkenhout which accounted for 77.37%.The virus carried rate of the Apodemus agrarius and R.norvegicus were 4.48% and 3.95% respectively.The virus carried rate of rodents were 0.044 and 0.036 respectively.The seasonal ebb and flow of the small animal density,the seasonal distribution of virus carried rate and the toxic index of rodents were by and large accord with the seasonal distribution of epidemic situation in humans,which all appeared from November to January of the next year and from April to June.The brumal peak was the main peak.The classification of the serum of the patients and the antigen of rodent lung had showed that the type of apodemus(Ⅰ) were respectively 60.91% and 53.52%,the type of house-rat(Ⅱ) were respectively 32.51% and 37.42%,and the unclassified ones were respectively 6.58% and 9.06%.Conclusion Taizhou city was the HFRS epidemic area of mixed types.The main type was the apodemus agrarius.Because of the high density of rodents and virus carried rate,it was reasonable to take the integrative preventive measures mainly by using bivalent vaccine and rodent control.