关键词: 莱姆病螺旋体, 血清, 间接免疫荧光试验, 酶联免疫吸附试验

Abstract: Objective Analysis the result of blood serum test for suspected Lyme disease patients,to clear the clinical manifestation and distributed situation of Lyme disease,and provides scientific basis for diagnosis and treatment of Lyme disease.Methods With indirect immunofluorescence assay(IFA) and enzyme-linked immunosorbent assay(ELISA),an investigation on antibodies(IgM,IgG) of Borrelia burgdorferi was carried out in sera of 827 suspected Lyme disease patients.Results From 2001 to 2006,we examined 827 suspected Lyme disease patients,135 patients of them were antibody positive(16.32%).The positive constitution ratio of the neurological disorders,cardiovascular system patients,skin disorders and fever patients was 65.18%(88/344),2.22%(3/39),22.22%(30/193),and 4.44%(6/102),respectively.Five specimens of 105 patients with arthritis was positive.Among the forty-four psychiatric derangements,three specimens was positive.Ninety-two percent of the total 135 positive patients had good curative effects after the treatment of antibiotic.There are Lyme disease in eighteen provinces,metropolises and autonomous regions in China.There are more confirm cases in Heilongjiang,Jilin,Neimenggu,Xinjiang than Qinghai,Sichuan,Guizhou,Yunnan,Zhejiang and so on.Conclusion There are lots of sporadic cases of Lyme disease in China,we can find out these patients early by blood serum test,and improved the efficient of diagnosis and treatment.