关键词: 噻吩类化合物, 光活化, 淡色库蚊

Abstract: Objective To determine the photolavicidal efficiency of several thiophenic compounds including α-terthienyl and some of its synthetic analogues against Culex pipiens pallens larvae in vivo and their structure-activity relationships. Methods The activity assays used drug-immersion method. Results All compounds showed less activity in dark. In irradiation of black light,LC₅₀ of α-T and SH were 2.075 4 ,3.305 4 μmol/L ,respectively. Effect of ultraviolet light ( λ 365 nm ,40 W ) and fluorescent light were same with that of black light. No obvious efficiency of ascorbic acid was found on the photolarvicidal activity of α-T and SH. Moreover,Br was more effective than I in activating the photolarvicidal activity,and haloid elements were more effective than hydrogen and methyl moiety whilst thiadiazoles possessed easier photoactivated property than oxadiazoles did. Conclusion Thiophenic compounds possessed powerful photolarvicidal activity against Culex pipiens pallens larvae and revealed obvious structure-activity relationships.