关键词: 抗凝血灭鼠剂, 黄胸鼠, 褐家鼠, 抗药性, 敏感性

Abstract: Objective To study the development and evolution of resistance to anticoagulant rodenticide in domestic rats since its use in Zhanjiang,Guangdong province and to provide scientific evidence for its use.Methods Rattus norvegicus and Rattus flavipectus were captured in varied periods from different areas of Zhanjiang.Their resistance to anticoagulant rodenticide was tested in lab based on the standard methods developed by a national collaboration study group.Results(Resistance to) the first-generation anticoagulant rodenticide gradually generated in individuals from the susceptible population of R.flavipectus ten years after its use,and a resistant population of R.flavipectus formed in Zhanjiang 17 years after its introduction.But,use of the second-generation anticoagulant rodenticide bromadiolone could reduce their resistance to the first-generation one.Frequency and methods to use anticoagulant rodenticides in varied areas the same period could influence the resistance in R.flavipectus,which could be maintained at a lower level in R.norvegicus,with a statistically significant difference between them((χ²=)(41.676),(P<(0.01)).Conclusion Rules of the development and evolution of resistance in rodents should be complied with in use of anticoagulant rodenticides,with periodically monitoring for it and properly selecting the first and second-generation anticoagulant rodenticides to ensure their effects and prolong their use period.