关键词: 肾综合征出血热, 带病毒率, 流行病学, 监测

Abstract: Objective To study the epidemic characteristics,determine the type of epidemic area,and make the preventive strategy of hemorrhagic fever with renal syndrome(HFRS). Methods Descriptive epidemiology methods and epidemic area survey were applied,epidemic situation among humans and the main host animals were analyzed. Samples were collected and fluorescent antibody(FA) was used to detect HV antigen,and immunofluoresce assay(IFA) for antibody detection. Results Since 1965,a total of 18 422 cases occurred in Quzhou city,the annual average incidence rate was 21.87/100 000. Besides,271 cases died,and the mortality was 1.47%. The prevalence seasons changed obviously in different years. The ratio of cases occurring in winter to that in spring was 7.22∶1 before 1980s' then decreased to 1.18∶1 after 2000. Farmer accounted for 82.41% of all cases and the ratio of male to female was 2.20∶1,25-54 years old cases accounted for 78.26%. The Kaihua and Qujiang district were the main epidemic zones in Quzhou city. From 2002-2004,the rat density in the field was 3.64%,whereas that of indoor was 4.20%. Rattus norvegicus,Apodemus agrarius were the predominant species,with the indice of two species of rats with virus was 0.026,0.034 respectively. During the three years,the indice of mixed species of rats were 0.048,0.036,0.032 respectively,correlating with incidence rate. Conclusion During the last 40 years,since the first case reported in 1965,the incidence rate showed the typical single-peak mode,which seems prevalence of HFRS follows the laws of sporadic occurring,prevailing,the dying out. Quzhou city is still a Apodemus-type predominant epidemic area. For these years,the HFRS morbidity reduced not only because of the decreasing chances of people contacting virus,but also the decreasing indexes of rat with virus. We still should further strengthen prevention of the HFRS.