中国媒介生物学及控制杂志

• 论著 • 上一篇    下一篇

驻石某部肾综合征出血热流行病学调查

汤芳1;李森林1;高东旗1;宋文静1;左曙青2;张云霜3;付云川3;江佳富2;曹务春2   

  1. 1北京军区疾病预防控制中心疾病监控科 北京100042;2军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室;3石家庄机械化步兵学院
  • 出版日期:2006-04-20 发布日期:2006-04-20

Investigation on Epidemiology of Hemorrhagic Fever with Renal Syndrome in a Military Unit, Shijiazhuang

TANG Fang; LI Sen-lin; GAO Dong-qi; SONG Wen-jing; ZUO Shu-qing; ZHANG Yun-shuang; FU Yun-chuan; JIANG Jia-fu; CAO Wu-chun   

  1. Center for Disease Control and Prevention of Beijing Military Command, Beijing 100042, China
  • Online:2006-04-20 Published:2006-04-20

摘要: 目的 探讨某部肾综合征出血热(HFRS)的流行状况、啮齿动物间汉坦病毒(HV)感染特点及HV基因型,为HFRS的预防控制提供科学依据。方法 夹夜法捕鼠,计算鼠密度,确定鼠种构成。针对HV基因M片段部分序列设计2种型特异性引物,应用RTPCR法检测宿主动物带病毒情况。结果 共捕获宿主动物14只,血清抗体阳性率为21.43%,RTPCR扩增检测出阳性标本1份,为褐家鼠,分型为汉城型阳性标本。密切接触人群血清抗体阳性率为3.64%。结论 该地区存在汉城型HV感染,提示应加强疫情监测,防止疫情的扩大蔓延。

关键词: 肾综合征出血热, 汉坦病毒, 流行病学

Abstract: Objective To identify the condition of hantavirus infection and genetype as well as to determine the risk factors of hantavirus infection in rodents captured in a military unit in order to provide scientific basis for prevention and control. Methods The captured rodents were classfied and the density of rodents was calculated. RT-PCR technique was used to amplify the partial M fragments. Results The infection rate of hantavirus in the 14 captured rodents was 21.43%. One sample (from Rattus norvegicus) was positive by RT-PCR amplified. Nucleotide sequences analysis showed that the virus detected all belonged to SEO-type. The crowd positive rate of IgG was 3.64%. Conclusion The SEO-HV infection of rodents exists in the military unit. It is necessary to reinforce epidemic surveillance to prevent spread of the disease.