关键词: 油茶皂素, 不育剂, 鼠类, 杀精作用, 抗生育功能

Abstract: Objective To study the antifertility function of sasanqua saponin sterilant against rodents.Methods The spermicidal effect in vitro and the antifertility ability in vivo on male mice of the sasanqua saponin sterilant in different concentration were mensurated.Results The spermicidal effect in vitro on male mice of the sasanqua saponin sterilant was provided with excellent positive relation in dosage-effect.The minimum spermicidal concentration being(0.05 mg/ml) in(3 min) of the sasanqua saponin sterilant was corresponded with nonoxynol spermicide and was lower than mandelic acid((0.1 mg/ml)) and citric acid((0.25 mg/ml)).Compared with the control group,after ig(125 mg/(kg·d)) sasanqua saponin sterilant for 4 weeks,(92.1%) alive sperm and(52.6%) sperm motility on male mice could be obviously reduced,and(64.0%) gravidity rate and(67.4%) alive embryo on female mice could be significantly decreased.Conclusion The sasanqua saponin sterilant was provided with obvious spermicidal effect in vitro and antifertility function in vivo.The sasanqua saponin spermicide or prophylactic and the antifertility medicament against rodents with entironment amity should be exploited in future.