肾综合征出血热沙鼠肾灭活疫苗的免疫持久性观察

中国媒介生物学及控制杂志

肾综合征出血热沙鼠肾灭活疫苗的免疫持久性观察

唐汉英; 陆群英; 朱智勇

浙江省卫生防疫站杭州310009

出版日期:1997-08-20 发布日期:1997-08-20

Observation of Immune Persistence of Inactivated HFRS Vaccine Cultured in M.unguiculatus Kidney Cell

Tang Han-ying; Lu Qun-ying; Zhu Zhi-yong

Zhejiang health and Anti-Epidemic Station,Hangzhou 310009

Online:1997-08-20 Published:1997-08-20

摘要/Abstract

摘要： 目的：观察肾综合征出血热（HFRS）沙鼠肾灭活疫苗的免疫持久性。方法：采用空斑减少中和试验检测静脉血中和抗体。结果：初免3针后中和抗体阳转率达90％左右，但持续时间不长，一年后降至30％加强1针免疫后则持续时间较长,6年后仍为50％左右。结论：此疫苗近期免疫效果较好，加强免疫十分必要。

关键词: HFRS灭活疫苗, 中和抗体, 持久性

Abstract: This paper describes that the inactivated HFRS vaccine (type I） cultured in M.unguiculatus kidney cell was used on human, the induced neutralization antibody were observed Persistently.The results showed that about 90% seroconversion rate of neutralization antibody occurred after primary injection three times.But the persistent time was shorter.It reduced 30% in a year after primary immunization.When the secondary immunizatiom (one injection) was done, the persistent time was longer.About 50% seroconversion rate of neutralization antibody occurred at six years after secondary immunization.There fore, this suggestes that the secondary immunization be necessary.

唐汉英; 陆群英; 朱智勇. 肾综合征出血热沙鼠肾灭活疫苗的免疫持久性观察[J]. 中国媒介生物学及控制杂志.

Tang Han-ying; Lu Qun-ying; Zhu Zhi-yong. Observation of Immune Persistence of Inactivated HFRS Vaccine Cultured in M.unguiculatus Kidney Cell[J]. Chines Journal of Vector Biology and Control.

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