关键词: 恙虫病, 外斐氏反应, 灵敏度, 特异度

Abstract: Objective:To explore on the diagnostic value of OXk antibody detection in diagnosis of tsutsugamushi disease.Methods:Serum specimens of tsutsugamushi disease cases and healthy controls were collected.All specimens were detected for OXk antibody by Weil-Felix reaction.Results:According to different intervals between the onset of disease and the sampling time,sensitivity and false negative rate of OXk antibody detection by Weil-Felix reaction,and its specificity and false positive rate also varied a lot.The best sampling time was 12 to 26 days after the onset of the disease.If the interval between the onset of disease and the sampling time went beyond 60 days,Weil-Felix reaction was not available in diagnosis of tsutsugamushi disease.Conclusion:OXk antibody detection has an important role in providing diagnostic clue of tsutsugamushi disease.It was suggested that the cut-off value of OXk antibody in single serum specimen was 1∶320.