关键词: 子午沙鼠, 戊肝病毒(HEV), 传代

Abstract: Objective:Test of HEV infection in Meriones meridianus step by step in generation.Method:The suspention liquid of waste of man,who was HEV patient,were injected into the abdominal cavities of healthy M.meridianus which were observed in 43-0 days afte injected.It was recorded for the clinical characters,Blood-enzyme,results of wasting HEVRNA,and the changes of liver's histology.The 7 bodies in the first time and 20 bodies both the second and third were injected step by step in generation respectively.Result:There were indistictively clinical characters,and similar reactions of blood-enzyme in all generations.There were two peak models of blood-enzyme from the 6 day to the 50 day after injectsd.Comparison of changes in liver histology was similar between the gerbils infected by HEV and the HEV patients.Conclusion:The experiments shown that gerbil can be infected by HEV step by step in three generations,in which the clinical characters is similar to HEV patients,and considered as laboratory animal model for HEV.