关键词: 小家鼠, 兄妹配对繁殖, 抗凝血剂杀鼠灵毒饵, 逐代淘汰

Abstract: Objective:To explore the development pattern of resistance in Mus musculus to anticoagultant rodenticides. Methods: The laboratory mice survived from feeding on 0.025% anticoagulant warfarin bait were employed as parents.The offsprings were fed on the same bait ,and the survivors mated and bred in brother-sister, generation after generation. Results: With the generation increasing, the survival rate of tested animals at first went up and then declined, while a decline tendency existed in female's fecundity. Conclusion: The pressure of continued selection by anticoagulant rodenticides made the fitness and vitality of Mus musculus population declined.