关键词: 肾综合征出血热, 灭活疫苗, 预防效果, 免疫增强, 免疫策略

Abstract: Objective:Observe the safety, serological efficacy, shortterm and longterm epidemiological efficacy character of Type Ⅰ inactivated HFRS vaccine in population in the focus of HFRS with high incidence of HFRS in Zhejiang province. Methods used in antibody test: Immunofluorecent antibody assay was used in testing specific IgG antibody and McroCPE method was used in testing the titer of neutralizing antibody. Result: 10 460 people were vaccinated, 97.30% of them completed their vaccination of full doses. 16 159 nonvaccinated people living in the same areas as the vaccinees were used as the control group. Two weeks after the injection of the third dose, the seroconversion rate by immunofluorecent antibody test (IgG) and neutralization test were 100.00%(67/67) and 44.44%, the GMTs of them were 72.12 and 4.62 respectively. Before reinforce,two weeks and 1 year after reinforce. The rates of seroconversion of immunofluorescent antibody by IFA method were 28.57%, 83.33% and 75.00%. The rates of seroconversion of neutralizing antibody by the Mcro-CPE method were 14.80%,55.56% and 35.00%. According to the short-term (1 year after primary immunization) and middle-term (2 years after primary immunization) observation, the vaccine was effective, and his protection rate in population was 100.00%. Till now, we have not find any antibody dependent immunization enhancement phenomenon among the inoculated population. Conclusion:HFRS vaccine was epidemiologically effective in the short-term and middle-term.