关键词: 急性氟乙酰胺中毒, 心肌酶谱, 动态变化

Abstract: Objective: To discuss the damage extent to myocardial and the changing orderliness of serum myocardial muscle enzyme in the patients with acute fluoroacetamide poisoning (AFAP). Methods: The level of serum enzyme including CK、CK-MB、GOT、LDH and HBDH in 25 cases of patients with AFAP measured by using the principles and methods of enzymic dynamic and observed sequentialy and trending from first day to tenth days while admitted in hospital. Results: (1)the average values of five serum enzyme in 25 cases of patients with AFAF were significantly higher than those in controls and they showed a regularly trendency changes (P<0.01). The peak values of five serum enzymes were measured in third and fourth days, it was 2-30 times to the controls, in which the CK and CK-MB varied in most and appeared in earlist for a long time. (2)The average values of five serum enzyme were significantly different among the light、middle and serious groups (P<0.01). Conclusions: The levels of serum myocardial enzyme in the patients with AFAP were obvious increasing, which was association with the extent of poisoning and the course of diseases closely. It suggested the more significant the enzymes increase, the more severe in the myocardial damage in the patients with AFAP.