关键词: 灰仓鼠, 多房棘球蚴, 动物模型

Abstract: Aim:To further study Cricetulus migratorius as an animal model for experimental infection of Alveolar echinococcosis.Method:By means of observation and study on the cyst development of E.multilocularis,reproduction of the infected mice and reinfection of the later generation born by the infected mice. Result: It was shown that the weight of the cyst masses was from 6.6g to 14.46g in 5 and 7 months after infection. There was a significant difference (P<0.01). C.migratorius could reproduce normally within four and half months after infection with E.multilocularis and that's no influence to the development of the cysts. The later generation didn't have inherent immunity to infection of E.multilocularis. Conclusion: The results demonstrated that C.migratorius has a high sensitivity to E.multilocularis infection, well developed cysts and rapid growth speed,the superiority of small body form, adaptability,endurance,and was easy to raise and reproduce as well. C.migratorius was proved to be an ideal experimental animal model for E.multilocularis infection.