Advances in research on anticoagulant rodenticide resistance

doi:10.11853/j.issn.1003.8280.2019.06.032

Abstract

Abstract: In recent years, a lot of research on anticoagulant rodenticide resistance, conducted by scholars at home and abroad, show that continuous use of anticoagulant rodenticides for 6 to 10 years will lead to rodenticide resistance in rodents. Rodenticide resistance can be effectively controlled by active resistance monitoring, scientific and rational use of drugs, cautious replacement of anticoagulant rodenticides, and integrated management and scientific rodent control. This paper summarizes the commonly used research methods and detection standards for anticoagulant rodenticide resistance at present, analyzes the cause of resistance, and discusses the current problems and shortcomings in the research on anticoagulant rodenticide resistance. Then management strategies and measures for anticoagulant rodenticide resistance are proposed to provide a reference for scientific rodent control.

Key words: Anticoagulant rodenticides, Rodenticide resistance

摘要： 近些年，国内外许多学者针对抗凝血杀鼠剂的抗药性做了大量研究，结果表明，抗凝血杀鼠剂连续使用6~10年鼠类会对其产生抗药性。积极开展抗药性监测，科学合理使用药物，谨慎更换抗凝血杀鼠剂，开展综合治理、科学灭鼠等措施可以有效防止抗药性的发生。该文概述了目前常用的抗凝血杀鼠剂抗药性研究方法和抗药性检测标准，分析了产生抗药性的原因，探讨现阶段抗凝血杀鼠剂抗药性研究领域存在的问题和不足，提出对抗凝血杀鼠剂抗药性的策略和措施，为科学灭鼠工作提供参考。

关键词: 抗凝血杀鼠剂, 抗药性

CLC Number:

DU Guo-yi, YAN Dong, WANG Zhi-yu, GAO Shao-kun. Advances in research on anticoagulant rodenticide resistance[J]. Chines Journal of Vector Biology and Control, 2019, 30(6): 725-728.

杜国义, 闫东, 王治宇, 高少坤. 抗凝血杀鼠剂抗药性的研究进展[J]. 中国媒介生物学及控制杂志, 2019, 30(6): 725-728.

References

[1] 黄秀清,冯志勇,颜世详. 抗凝血灭鼠剂可持续使用技术研究[J]. 广东农业科学,2003(6):31-34. DOI:10.3969/j.issn. 1004-874X.2003.06.014.
[2] Boyle CM. Case of apparent resistance of Rattus norvegicus Berkenhout to anticoagulant poisons[J]. Nature,1960,188(4749):517. DOI:10.1038/188517a0.
[3] 董天义,阎丙申. 抗凝血灭鼠剂研究进展[J]. 医学动物防制,1998,14(4):61-67.
[4] 孙毅,郭天宇,董天义. 家栖鼠抗药性研究进展[J]. 中华卫生杀虫药械,2004,10(3):164-167. DOI:10.3969/j.issn.1671-2781.2004.03.011.
[5] Buckle AP,Klemann N,Prescott CV. Brodifacoum is effective against Norway rats (Rattus norvegicus) in a tyrosine139cysteine focus of anticoagulant resistance in Westphalia,Germany[J]. Pest Manag Sci,2012,68(12):1579-1585. DOI:10.1002/ps.3352.
[6] Greaves JH,Ayers PB. Multiple allelism at the locus controlling warfarin resistance in the Norway rat[J]. Genet Res,1982,40(1):59-64. DOI:10.1017/S0016672300018905.
[7] Greaves JH,Shepherd DS,Quy R. Field trials of second-generation anticoagulants against difenacoum-resistant Norway rat populations[J]. J Hyg (Lond),1982,89(2):295-301. DOI:10.1017/S0022172400070820.
[8] 曹煜,戴安锁,刘宇,等. 北京市褐家鼠对第一代抗凝血灭鼠剂的抗药性调查[J]. 中国媒介生物学及控制杂志,2007,18(3):187-189. DOI:10.3969/j.issn.1003-4692.2007.03.003.
[9] 董天义. 抗凝血灭鼠剂应用研究[M]. 北京:中国科学技术出版社,2001:1-215.
[10] 陈火华,黄善盛,朱宇平,等. 江门市家栖鼠对第一代抗凝血灭鼠剂抗药性研究[J]. 中国媒介生物学及控制杂志,2007,18(5):360-362. DOI:10.3969/j.issn.1003-4692.2007.05.005.
[11] 高志祥,施大钊,郭永旺,等. 北京地区黑线姬鼠对杀鼠灵抗药性的测定[J]. 中国媒介生物学及控制杂志,2008,19(2):90-92. DOI:10.3969/j.issn.1003-4692.2008.02.002.
[12] 易建荣,林立丰,伍任初,等. 广州市家栖鼠对第一代抗凝血灭鼠剂抗药性研究[J]. 中国媒介生物学及控制杂志,2004,15(5):357-359. DOI:10.3969/j.issn.1003-4692.2004.05.006.
[13] 鼠类抗药性监测协作组. 1991年家栖鼠对抗凝血灭鼠剂抗药性的检验方法[J]. 中国媒介生物学及控制杂志,1991,2(5):339-340.
[14] 孙毅,易建荣,梁练,等. 应用凝血反应检测褐家鼠种群抗药性水平[J]. 中国媒介生物学及控制杂志,2006,17(1):8-10. DOI:10.3969/j.issn.1003-4692.2006.01.002.
[15] 董天义. 家栖鼠的抗药性及对策研究(续)[J]. 中国媒介生物学及控制杂志,2000,11(5):384-388. DOI:10.3969/j.issn.1003-4692.2000.05.022.
[16] 冯志勇,姚丹丹,黄立胜,等. 黄毛鼠对第一代抗凝血灭鼠剂的抗药性监测[J]. 植物保护学报,2007,34(4):420-424. DOI:10.3321/j.issn:0577-7518.2007.04.017.
[17] 孙仲秋,李奎山,孙启廷. 达乌尔黄鼠对杀鼠灵的敏感性测定[J]. 中国地方病防治杂志,1990,5(3):163-164.
[18] 梁练,张世炎,胡杰,等. 家栖鼠对抗凝血灭鼠剂抗药性研究与应用前景分析[J]. 中国媒介生物学及控制杂志,2006,17(3):180-182. DOI:10.3969/j.issn.1003-4692.2006.03.007.
[19] 王军建,陈立奇,周纯良,等. 黄胸鼠对杀鼠灵和溴敌隆抗药性调查报告[J]. 中国媒介生物学及控制杂志,2002,13(1):7-9. DOI:10.3969/j.issn.1003-4692.2002.01.002.
[20] 王军建,陈立奇,龙浩宇. 黄胸鼠对抗凝血灭鼠剂交叉抗药性试验观察[J]. 中国媒介生物学及控制杂志,2002,13(3):169-171. DOI:10.3969/j.issn.1003-4692.2002.03.002.
[21] Redfern R,Gill JE. The development and use of a test to identify resistance to the anticoagulant difenacoum in the Norway rat (Rattus norvegicus)[J]. J Hyg (Lond),1978,81(3):427-431. DOI:10.1017/S0022172400025316.
[22] Plez HJ,Rost S,Hünerberg M,et al. The genetic basis of resistance to anticoagulants in rodents[J]. Genetics,2005,170(4):1839-1847. DOI:10.1534/genetics.104.040360.
[23] 宋英,李宁,王大伟,等. 鼠类对抗凝血类灭鼠剂抗药性的遗传机制[J]. 中国科学:生命科学,2016,46(5):619-626. DOI:10.1360/N052016-00161.
[24] Ishizuka M,Okajima F,Tanikawa T,et al. Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo[J]. Drug Metab Dispos,2007,35(1):62-66. DOI:10.1124/dmd.106.011775.
[25] Markussen MDK,Heiberg AC,Fredholm M,et al. Differential expression of cytochrome P450 genes between bromadiolone-resistant and anticoagulant-susceptible Norway rats:a possible role for pharmacokinetics in bromadiolone resistance[J]. Pest Manag Sci,2008,64(3):239-248. DOI:10.1002/ps.1506.
[26] 李玉莲,梁练,张世炎,等. 广东省安铺黄胸鼠和褐家鼠对杀鼠灵的抗药性监测[J]. 中国地方病防治杂志,2005,20(3):144-145. DOI:10.3969/j.issn.1001-1889.2005.03.006.
[27] 段天一,孙启廷,张芳,等. 达乌尔黄鼠对溴敌隆灭鼠剂抗药性的研究[J]. 中国地方病防治杂志,2012,27(4):279-280.