Abstract: Objective To investigate the epidemiological characteristics of hemorrhagic fever with renal syndrome (HFRS) in humans and rodents at surveillance sites in Liaoning province, China, and to provide a scientific basis for formulating prevention and control measures. Methods Data on the epidemic situation of HFRS from 2012 to 2016 were collected from 5 surveillance sites in Liaoning province, and investigations on host animals were performed in both spring and autumn. The trap-at-night method was used to determine rodent density. Hantavirus antigen and antibody tests were performed for rodent lung and blood film specimens. Results The incidence rate reported by each surveillance site was between 0.49/100 000 and 16.85/100 000. The five-year mean rodent density was 4.03% in residential areas and 4.09% in the field. The dominant rodent species was Rattus norvegicus in residential areas (72.91%) and Apodemus agrarius in the wild (74.55%). The virus-carrying rate and infection rate in rodents were 4.57% and 13.94%, respectively. Conclusion R. norvegicus and A. agrarius are the main host animals and infection sources of HFRS in Liaoning province. It is necessary to formulate targeted prevention and control strategies and measures specific to the incidence characteristics of HFRS at different surveillance sites due to the relatively significant differences in rodent density and virus-carrying rate between surveillance sites.

Key words: Hemorrhagic fever with renal syndrome, National surveillance site, Host animal, Surveillance

摘要： 目的 了解辽宁省肾综合征出血热（HFRS）监测点该病人间和鼠间流行特征，为制定防治措施提供科学依据。方法 收集2012-2016年辽宁省5个监测点HFRS疫情资料，并分别于春、秋两季开展宿主动物调查，采用夹夜法调查鼠密度，对鼠肺和鼠血膜标本进行汉坦病毒抗原和抗体检测。结果 各监测点报告HFRS发病率在0.49/10万~16.85/10万之间；5年平均鼠密度居民区为4.03%，野外为4.09%；鼠种构成居民区以褐家鼠为优势鼠种（72.91%），野外以黑线姬鼠为优势鼠种（74.55%）；鼠带病毒率为4.57%，鼠感染率为13.94%。结论 褐家鼠和黑线姬鼠是辽宁省HFRS的主要宿主动物和传染源；各监测点鼠密度和鼠带病毒率差异较大，应结合不同监测点HFRS的发病特点，制定有针对性的防治对策和措施。

关键词: 肾综合征出血热, 国家级监测点, 宿主动物, 监测