Research advances in mosquito resistance to insecticides mediated by cytochrome P450

doi:10.11853/j.issn.1003.8280.2019.05.027

Abstract

Abstract: Cytochrome P450 is an important family of enzymes ubiquitously expressed in organisms. It can metabolize a variety of endogenous and exogenous substances, and plays an important role in the metabolism and detoxification of insecticides in insects. The metabolism and detoxification of insecticides mediated by P450 are characterized by universality and cross resistance, and the mechanisms involve an increase in enzyme expression and a change in enzyme activity. This article reviews some new research advances in the P450-mediated insecticide resistance of mosquitoes.

Key words: Mosquitoes, Cytochrome P450, Insecticide resistance, Molecular mechanism

摘要： 细胞色素P450是一类广泛分布于生物体内的重要酶系，能够代谢多种内源性和外源性物质，在昆虫对杀虫剂代谢解毒方面起着重要作用。P450介导的杀虫剂代谢解毒作用具有普遍性和交互抗性的特点，其机制涉及酶表达量增加和酶活性改变。该文以蚊虫为例综述了P450介导的抗药性一些新进展。

关键词: 蚊虫, 细胞色素P450, 抗药性, 分子机制

CLC Number:

WANG Yang, SONG Xiao, CHENG Peng, GONG Mao-qing. Research advances in mosquito resistance to insecticides mediated by cytochrome P450[J]. Chines Journal of Vector Biology and Control, 2019, 30(5): 589-592.

王洋, 宋晓, 程鹏, 公茂庆. 细胞色素P450介导的蚊虫抗药性研究进展[J]. 中国媒介生物学及控制杂志, 2019, 30(5): 589-592.

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