Abstract: Objective To provide a scientific basis for the prevention and control of brucellosis by epidemiologic investigation and analysis of a familial cluster of brucellosis case. Methods The field epidemiological investigation method was used to analyze the pathogenesis and source of infection of the three cases, and the tiger red plate agglutination test and tube agglutination test were used to detect the antibody. Results On April 17, 2017, the Xianghe County Center for Disease Control and Prevention in Langfang, Hebei province reported three cases of clinical diagnosis of brucellosis in Baodi district. There were three cases of infection with both tests positive in the epidemic. The source of infection was sick animals, especially miscarriage tissue from the sick ewe. The patients had no effective protection in daily work. Conclusion The awareness of protection during daily work and related knowledge and skills of identification of animals with brucellosis should be improved among employees to effectively cut off the transmission route of brucellosis and thus achieve the prevention and control of this disease.

Key words: Brucellosis, Epidemiological investigation, Laboratory test

摘要： 目的 通过对1起布鲁氏菌病（布病）家庭聚集性疫情调查分析，为布病防控提供科学依据。方法 采用现场流行病学调查方法，对病例发病过程及感染来源进行分析；采用虎红平板凝集试验及试管凝集试验检测抗体。结果 2017年4月17日河北省廊坊市香河县疾病预防控制中心报告宝坻区3例布病临床诊断病例，2种检测方法均为阳性，感染来源为接触病畜，特别是患病母羊流产物。病例在日常劳作中无有效防护。结论 布病的防控可通过提高从业人员日常劳作的防护意识及甄别布病病畜的相关知识与技能等，有效切断布病传播途径，进而达到防控效果。

关键词: 布鲁氏菌病, 流行病学调查, 实验室检测