Abstract: Objective To analyze the epidemiological characteristics of hemorrhagic fever with renal syndrome (HFRS) and the virus-carrying rate of host animals (rodents) in Tiantai county, Zhejiang province, China, and to provide a scientific basis for effective control of HFRS. Methods The data of the epidemic situation of HFRS in Tiantai were analyzed using descriptive epidemiological method. Rodents were captured using traps and then investigated. Indirect immunofluorescence assay was adopted to identify specific IgG antibody. Direct immunofluorescence assay was used to identify hantavirus antigen in the mouse lung. Results A total of 452 cases of HFRS were reported from 2001 to 2011 in the whole county, with 3 deaths, an annual average incidence of 7.27/10⁵, and a mortality rate of 0.66%. Throughout the whole county, the incidence of HFRS was primarily distributed in the towns and villages in the plain region at both sides of Shifeng River. This disease occurred in each month throughout the year, with May to July and October to December as high-incidence periods, accounting for 31.19% and 34.29% of all cases. People aged between 26-64 years were most easily infected, accounting for 86.06% of all cases. As for occupation, peasants constituted the majority of all cases, accounting for 82.52%. The ratio of male cases to female cases was 2.90:1. The coincidence rate of clinical diagnosis in these cases was 82.83%; the recessive infection rate of healthy population was 1.27%. The serological positive rate of mice was 5.20%. Apodemus agrarius was the dominating species in the field mice, followed by Rattus losea. R. norvegicus was dominant species in the house mice. The virus carrying rate of the mouse lung was 10.62%. Conclusion HFRS cases occurred every year in Tiantai county, Zhejiang province, China, and the virus carrying rate of host animals was relatively high. Measures should be taken to enhance surveillance and control of HFRS.

Key words: Hemorrhagic fever with renal syndrome, Surveillance, Analysis

摘要： 目的 分析天台县肾综合征出血热(HFRS)流行特征和宿主带病毒情况, 为制定针对性的防治措施提供科学依据。方法 用描述流行病学方法分析天台县HFRS疫情资料, 调查宿主动物, 用间接免疫荧光法(IFA)检测特异性IgG抗体, 用直接免疫荧光法(FA)检测鼠肺汉坦病毒(HV)抗原。结果 2001-2011年全县累计报告病例452例, 死亡3例, 年平均发病率7.27/10万, 病死率0.66%;全县HFRS发病具有相对集中和稳定的特点, 主要分布在始丰溪两岸地势平坦的乡镇村;全年各月均有发病, 但以5-7月和10-12月发病较多, 分别占病例总数的31.19%和34.29%;发病以26～64岁人群为主, 占病例总数的86.06%;职业以农民为主, 占82.52%;男女性别比为2.90:1;病例的临床诊断符合率为82.83%;健康人群隐性感染率为1.27%;鼠类血清阳性率为5.20%, 野外以黑线姬鼠为优势鼠种, 其次为黄毛鼠;室内以褐家鼠为优势鼠种, 鼠肺带病毒率为10.62%。结论 天台县每年均有HFRS病例发生, 且宿主动物带病毒率较高, 需继续加强监测, 进一步加大综合防制力度。

关键词: 肾综合征出血热, 监测, 分析