Abstract: Objective To investigate the level of the resistance of Rattus tanezumi to anticoagulant rodenticide (warfarin) in the villages and towns (epidemic foci of plague) of Xingyi city, Guizhou province, China. Methods Each individual of R. tanezumi was raised in a single cage in no-choice feeding test. R. tanezumi was given warfarin for 9 day and then fed normally. The whole test period was 25 day. Results A total of 23 (12♂/11♀) eligible individuals of R. tanezumi were enrolled in the test, with body weights of 67-170 g. Thirteen rats were killed, with lethal doses of 117.65-293.75 mg/kg and lethal times of 6.62 (4-10) day. Ten rats survived the test, with warfarin doses of 284.76- 522.73 mg/kg. Of all rats, 43.48% developed resistance to warfarin. Conclusion There are individuals and populations of R. tanezumi which have resistance to warfarin in Xingyi city, Guizhou province, China.

Key words: Rattus tanezumi, Insecticide resistance, Plague

摘要： 目的 调查贵州省鼠疫疫源地兴义市疫源乡镇黄胸鼠对抗凝血杀鼠剂的抗性水平。方法 采用无选择摄食实验, 对试鼠单笼饲养, 进行9 d攻毒后正常饲养观察, 总实验期25 d。结果 实验共选合格试鼠23只(12♂/11♀), 体重67～170 g, 其中13只鼠死亡, 死亡剂量117.65～293.75 mg/kg, 死亡时间6.62(4～10)d;10只鼠成活, 成活剂量284.76～522.73 mg/kg;抗药性发生率为43.48%。结论 兴义市黄胸鼠对杀鼠灵存在抗药性个体和抗药性种群。

关键词: 黄胸鼠, 抗药性, 鼠疫