Abstract:

Objective To monitor Borrelia burgdorferi infection and the incidence of Lyme disease and its epidemic trends in the natural foci of Lyme disease in Southern Mountainous Area of Urumqi, providing the basis for the development of strategies for the control and prevention of the disease. Methods The indirect immunofluorescent assay (IFA) and western blot (WB) were used to detect serum IgM and IgG antibodies against B. burgdorferi, with urine samples from 2 patients tested for DNA of B. burgdorferi by PCR. The cases of B. burgdorferi infection and Lyme disease were identified by the clinical features, detailed medical history and physical examination in combination with laboratory findings. Results The average infection rate with B. burgdorferi was 16.14% (36/223), with 27 cases including 6 cases identified during 1999 to 2002 and 21 cases during 2003 to 2006 confirmed the diagnosis of Lyme disease, who manifested multiple organ impact including the cardiovascular system, central nervous system, the skin, the eyes and the joints. And erythema was also seen in 44.44%(12/27) of children infected with B. burgdorferi. Conclusion There are a relatively high rate of infection with B. burgdorferi and typical cases in the pastoral areas and, semi-pastoral and semi-agricultural areas in Southern Mountainous Area of Urumqi. Great importance is to be attached to the control and prevention of the disease.

Key words: Borrelia burgdorferi, Infection, Lyme disease, Investigation

摘要：

目的 监测乌鲁木齐南山大小松沟莱姆病自然疫源地人群伯氏疏螺旋体感染与莱姆病发病情况及流行趋势，为制定防制对策提供依据。方法 采用间接免疫荧光试验(IFA)和蛋白免疫印迹(WB)方法，对223人检测血清抗伯氏疏螺旋体抗体(IgM、IgG)，2人应用聚合酶链反应(PCR)技术检测尿液中伯氏疏螺旋体DNA。对有蜱叮咬和犬咬史，并有莱姆病相关临床表现者，详细询问病史和查体，结合血清学检测和尿液PCR结果，确定伯氏疏螺旋体感染与莱姆病病例。结果 伯氏疏螺旋体平均感染率为16.14%(36/223)， 确诊莱姆病27例(1999－2002年6例；2003－2006年21例)，包括皮肤、神经系统、眼、心脏和关节多系统损害。少年儿童感染后，出现各型红斑占44.44%(12/27)。结论 乌鲁木齐市山地牧区和半农半牧地区人群均存在较高的莱姆病感染率，并有典型病例，当地应重视莱姆病的预防和治疗。

关键词: 伯氏疏螺旋体, 感染, 莱姆病, 调查