Abstract:

Objective To analyze the epidemiological surveillance data on brucellosis in Chaoyang city from 1999 to 2008, infer the possible prevalent strain from the information and identify the major source of infection, providing the basis for prevention and control of brucellosis. Methods Based on epidemiological surveillance, sporadic cases and outbreaks from 1999 to 2008 among the focal population in the key areas and 7 counties of the city, as well as cattle and sheep, were subject to serological tests. The sera samples of the 3 groups were collected for antibody detection. Spearman analysis was conducted to identify the correlation between the annual incidence in humans and the number of cattle and sheep herds，the annual incidence and the antibody positive rate of cattle and sheep sera samples, and the antibody seroprevalence in the focal population and that in cattle and sheep．Results The annual incidence was noticeably correlated with the number of cattle and sheep herds and the seroprevalence in sheep (r=0.779, P<0.01; r=0.816, P<0.01; r=0.857, P<0.01)．Blood culture of the pathogens collected from 18 patients in 2009 revealed 2 strains of type 3 Brucella melitensis. Conclusion Brucella melitensis was the major cause of brucellosis epidemics in Chaoyang city, indicating that sheep should be specifically monitored in prevention and control of brucellosis.

Key words: Brucellosis, Antibody in humans, Sheep herds, Sheep antibody

摘要：

目的 通过对朝阳市1999－2008年布鲁氏菌病(布病)的流行病学监测资料进行分析，推断布病流行菌种，找出主要传染源，为布病防治工作提供科学依据。方法 采用流行病学监测方法，于1999－2008年对重点地区的重点人群、全市7个县(市、区)的散发病例及暴发病例、畜间牛、羊开展血清学检测。通过对3类群体的血清进行抗体检测，运用Spearman相关的分析方法，找出人群年发病数与牛、羊存栏数，人群年发病数与牛、羊血清抗体阳性率，重点人群血清抗体阳性率与牛、羊血清抗体阳性率的关系。结果 人群年发病数与牛、羊存栏数及与羊血清阳性率明显相关(r=0.779，P<0.01； r=0.816，P<0.01； r=0.857，P<0.01)； 2009年对18例布病患者进行病原菌血培养，有2株为布鲁氏菌羊种菌3型。结论 朝阳市布病以羊种菌为主要流行菌种，在防治中羊应作为主要的监管对象。

关键词: 布鲁氏菌病, 人群血清抗体, 羊存栏数, 羊血清抗体