Caenorhabditis elegans a new model to study the pathogenic mechanisms of bacteria

Abstract

Abstract:

Caenorhabditis elegans, studied in great detail, is simple and cheap enough to be used as a new model organism for analysis of bacterial pathogens. Currently, it is utilized to identify the virulence factors, pathogenetic mechanisms, host?pathogen interactions, biofilm formation and drug resistance of bacteria such as Pseudomonas aeruginosa, Enterococcus faecium, Staphylococcus aureus, Shigella flexneri, Pseudomonas aeruginosa, Yersinia, Listeria, Salmonella enterica, Burkholderia, Streptococcus pyogenes, Salmonella typhimurium, Bacillus thuringiensis, Serratia marcescens, Cryptococcus and Microbacterium nematophilum. Since C. elegans feeds on bacteria, determination of bacterial pathogenicity is based on variations in the survival curve of strains that have consumed the specific bacteria.

Key words: Caenorhabditis elegans, Model organism, Pathogenic bacteria, Pathogenicity

摘要：

秀丽隐杆线虫以其背景资料丰富、便于操作和观察、廉价等特点，成为用来尝试研究病原细菌的新模型。目前已经将秀丽隐杆线虫作为模式生物，应用于铜绿假单胞菌、粪肠球菌、金黄色葡萄球菌、痢疾杆菌、绿脓杆菌、耶尔森菌、李斯特菌、沙门菌、类鼻疽假单胞菌、化脓性链球菌、鼠伤寒沙门菌、苏云金芽孢杆菌、粘质沙雷菌、隐球菌、细小棒状杆菌等多种病原菌，来研究病原菌的毒力因子、致病机制、与宿主相互作用、生物膜形成、耐药等各个方面。秀丽隐杆线虫以细菌为食，使其以病原菌为食后生存曲线的变化作为判断病原菌致病性的具体方法。

关键词: 秀丽隐杆线虫, 模式生物, 病原菌, 致病性

CLC Number:

R378

XU Dong-Lei, KAN Biao. Caenorhabditis elegans a new model to study the pathogenic mechanisms of bacteria[J]. Chines Journal of Vector Biology and Control, 2010, 21(3): 283-285.

徐冬蕾，阚飙. 秀丽隐杆线虫作为研究病原细菌致病机制的新模型[J]. 中国媒介生物学及控制杂志, 2010, 21(3): 283-285.

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