Abstract:

Objective　To evaluate the impact of compound levonorgestrel tablets on the fertility of female mice for providing the basis for rodent control with contraceptives. Methods　A total of 60 female mice were randomly divided into a control group and two experimental groups. The mice in the control group were normally fed, while those in the experimental groups were fed 12 and 24 mg/kg of toxic baits, respectively. The female mice were paired with male mice in a ratio of 2∶1 beyond 48 h after feeding for mating test to determine their fertility. Results　The fertility rates of the 12 mg/kg and 24 mg/kg groups were 15.00%  and  0,  respectively,  lower  than  that (80.00%) of the control group (χ²＝33.43, P＝0.00). The average litter sizes of the 12 mg/kg and 24 mg/kg groups were 6.25 and 4.75, respectively, both lower than that (10.70) of the control group (F＝10.30, P＝0.00). The average time from the pairing to birth of the two experimental groups was 36.85 and 42.60 d, respectively, both longer than that (27.25 d) of the control group (F＝9.65, P＝0.00). The average birth control time of the 12 mg/kg and 24 mg/kg groups was 9.60 and 15.35 d, respectively. Conclusion　Compound levonorgestrel tablets significantly compromised the fertility of female mice, indicative of the potential value of this drug in rodent control.

Key words: Compound levonorgestrel, Female mice, Fertility

摘要：

目的　探索复方左炔诺孕酮对雌鼠生育能力的影响，为应用避孕药物进行鼠害控制提供科学依据。方法　将60只雌性小鼠随机分为对照组和2个实验组，对照组喂食正常饲料，实验组喂食12和24 mg/kg浓度的毒饵，喂食48 h后以2∶1的雌雄比例合笼，进行交配试验，检测其生育能力。结果　12和24 mg/kg实验组的生育率分别为15.00%和0，低于对照组的生育率（80.00%）（χ²＝33.43，P＝0.00）；12和24 mg/kg实验组平均产仔数分别为6.25和4.75只，较对照组平均产仔数（10.70只）少（F＝10.30，P＝0.00）；12和24 mg/kg实验组合笼后至产仔平均时间分别为36.85和42.60 d，亦低于对照组平均时间（27.25 d）（F＝9.65，P＝0.00）；12和24 mg/kg实验组的平均控制生育时间分别为9.60和15.35 d。结论　复方左炔诺孕酮影响雌鼠生育能力作用明显，复方左炔诺孕酮在鼠害控制方面有一定的应用潜力。

关键词: 复方左炔诺孕酮, 雌鼠, 生育能力