关键词: 肾综合征出血热, 监测, 流行病学

Abstract: Objective By analyzing the epidemical characteristics and the trends of hemorrhagic fever with renal syndrome (HFRS) in Guangzhou in 2004 to provide theoretic basis for formulating the control measures. Methods Data on the incident rate was collected from the whole city to describe the epidemical characteristics of HFRS,and immunofluoresence assay(IFA) was used to detect the antibodies in HFRS patients' serums and the antigens in rats' lung tissues respectively. Results 65 patients were seropositive in 2004 (with an annual incident rate of 0.59/100 000,a mortality rate of 0.02/100 000 and a mortality rate of 3.08% percent of the patients) and most of them were young male workers and waiters. Most of the cases were distributed in Haizhu and Tianhe districts. Dominant peak was observed in spring and in autumn. Surveillance on rats demonstrated 1.8% rats carried type Ⅱ hantavirus (with a density of 10.5%) and the main host was Rattus norvegicus. The territorial distribution of rats with virus coincides and that of HFRS patients were similar the seasonal distribution of rats with virus was earlier than that of HFRS patients. Conclusion The incident rate of HFRS in Guangzhou in 2004 showed a stable trend,but the risk factors still widely exist. Such accordingly measures must be taken as the surveillance on patients and rats,preventing and killing rats,the injection of main populations and so on in order to decrease the incidence of HFRS.